Abstract

Sepsis mortality may be improved by early recognition and appropriate treatment based on evidence-based guidelines. An intervention was developed that focused on earlier identification of sepsis, early antimicrobial administration, and an educational program that was disseminated throughout all hospital units and services. There were 1331 patients with sepsis during the intervention period and 1401 patients with sepsis during the control period. After controlling for expected mortality, patients in the intervention period had 30% lower odds of dying (odds ratio = 0.70, 95% confidence interval [CI] = 0.57 to 0.84). They also had 1.07 fewer days on average in the intensive care unit (95% CI = −1.98 to −0.16), 2.15 fewer hospital days (95% CI = −3.45 to −0.86), and incurred on average $1949 less in hospital costs, although the effect on costs was not statistically significant. Continued incremental improvement and sustainment is anticipated through organizational oversight, continued education, and initiation of an automated electronic sepsis alert function.

Original languageEnglish (US)
Pages (from-to)56-63
Number of pages8
JournalAmerican Journal of Medical Quality
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2016

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Sepsis
Confidence Intervals
Hospital Units
Mortality
Hospital Costs
Intensive Care Units
Odds Ratio
Guidelines
Education
Costs and Cost Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Health Policy

Cite this

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title = "Improving Outcomes in Patients With Sepsis",
abstract = "Sepsis mortality may be improved by early recognition and appropriate treatment based on evidence-based guidelines. An intervention was developed that focused on earlier identification of sepsis, early antimicrobial administration, and an educational program that was disseminated throughout all hospital units and services. There were 1331 patients with sepsis during the intervention period and 1401 patients with sepsis during the control period. After controlling for expected mortality, patients in the intervention period had 30{\%} lower odds of dying (odds ratio = 0.70, 95{\%} confidence interval [CI] = 0.57 to 0.84). They also had 1.07 fewer days on average in the intensive care unit (95{\%} CI = −1.98 to −0.16), 2.15 fewer hospital days (95{\%} CI = −3.45 to −0.86), and incurred on average $1949 less in hospital costs, although the effect on costs was not statistically significant. Continued incremental improvement and sustainment is anticipated through organizational oversight, continued education, and initiation of an automated electronic sepsis alert function.",
author = "Armen, {Scott B.} and Freer, {Carol V.} and Showalter, {John W.} and Tonya Crook and Whitener, {Cynthia J.} and Cheri West and Terndrup, {Thomas E.} and Marissa Grifasi and DeFlitch, {Christopher J.} and Hollenbeak, {Christopher S.}",
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Improving Outcomes in Patients With Sepsis. / Armen, Scott B.; Freer, Carol V.; Showalter, John W.; Crook, Tonya; Whitener, Cynthia J.; West, Cheri; Terndrup, Thomas E.; Grifasi, Marissa; DeFlitch, Christopher J.; Hollenbeak, Christopher S.

In: American Journal of Medical Quality, Vol. 31, No. 1, 01.01.2016, p. 56-63.

Research output: Contribution to journalArticle

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N2 - Sepsis mortality may be improved by early recognition and appropriate treatment based on evidence-based guidelines. An intervention was developed that focused on earlier identification of sepsis, early antimicrobial administration, and an educational program that was disseminated throughout all hospital units and services. There were 1331 patients with sepsis during the intervention period and 1401 patients with sepsis during the control period. After controlling for expected mortality, patients in the intervention period had 30% lower odds of dying (odds ratio = 0.70, 95% confidence interval [CI] = 0.57 to 0.84). They also had 1.07 fewer days on average in the intensive care unit (95% CI = −1.98 to −0.16), 2.15 fewer hospital days (95% CI = −3.45 to −0.86), and incurred on average $1949 less in hospital costs, although the effect on costs was not statistically significant. Continued incremental improvement and sustainment is anticipated through organizational oversight, continued education, and initiation of an automated electronic sepsis alert function.

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