In utero exposure to cigarette smoking, environmental tobacco smoke and reproductive hormones in us girls approaching puberty

Audra L. Gollenberg, O. Yaw Addo, Zhiwei Zhang, Mary L. Hediger, John H. Himes, Peter A. Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background/Aims: Evidence is unclear whether prenatal smoking affects age at menarche and pubertal development, and its impact upon hormones has not been well studied. We aim to identify potential pathways through which prenatal smoking and environmental tobacco smoke (ETS) affect reproductive hormones in girls approaching puberty. Methods: We examined the association between prenatal smoking, current ETS and luteinizing hormone (LH) and inhibin B (InB) in 6- to 11-year-old girls in the 3rd National Health and Nutrition Examination Survey, 1988-1994. Parents/guardians completed interviewer-assisted questionnaires on health and demographics at the time of physical examination. Residual blood samples were analyzed for reproductive hormones in 2008. Results: Of 660 girls, 19 and 39% were exposed to prenatal smoke and current ETS, respectively. Accounting for multiple pathways in structural equation models, prenatally exposed girls had significantly lower LH (β = -0.205 log-mIU/ml, p < 0.0001) and InB (β = -0.162, log-pg/ml, p < 0.0001). Prenatal smoking also influenced LH positively and InB negatively indirectly through BMI-for-age. ETS was positively associated with LH, but not with InB. Conclusion: Exposure to maternal smoking may disrupt reproductive development manifesting in altered hormone levels near puberty.

Original languageEnglish (US)
Pages (from-to)36-44
Number of pages9
JournalHormone Research in Paediatrics
Volume83
Issue number1
DOIs
StatePublished - Mar 6 2015

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Puberty
Smoke
Tobacco
Luteinizing Hormone
Smoking
Hormones
Maternal Exposure
Menarche
Nutrition Surveys
Structural Models
Physical Examination
Parents
Demography
Interviews
inhibin B
Health

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Gollenberg, Audra L. ; Addo, O. Yaw ; Zhang, Zhiwei ; Hediger, Mary L. ; Himes, John H. ; Lee, Peter A. / In utero exposure to cigarette smoking, environmental tobacco smoke and reproductive hormones in us girls approaching puberty. In: Hormone Research in Paediatrics. 2015 ; Vol. 83, No. 1. pp. 36-44.
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In utero exposure to cigarette smoking, environmental tobacco smoke and reproductive hormones in us girls approaching puberty. / Gollenberg, Audra L.; Addo, O. Yaw; Zhang, Zhiwei; Hediger, Mary L.; Himes, John H.; Lee, Peter A.

In: Hormone Research in Paediatrics, Vol. 83, No. 1, 06.03.2015, p. 36-44.

Research output: Contribution to journalArticle

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