In utero exposure to lead and cord blood total IgE. Is there a connection?

Isabella Annesi-Maesano, R. Pollitt, Gary King, J. Bousquet, G. Hellier, J. Sahuquillo, G. Huel

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Lead exposure and total immunoglobulin E (IgE) have been shown to be positively related in animals and humans even at lead levels below those recognized as toxic. In the last decades, exposure to lead has become more frequent in urban areas of industrialized as well as of developing countries where IgE-mediated allergy prevalence has also increased. Methods: We examined for the first time the relationship between in utero exposure to lead and cord blood total IgE in two samples of 137 and 237 mother-newborn pairs, respectively, recruited in Paris. Results: Cord blood IgE was positively related to hair lead level at birth, providing an integrated measure of long-term exposure in utero, in each cohort (Spearman's coefficient r = 0.32, P < 0.001 and r = 0.19, P < 0.01, respectively) and in the combined cohort (r = 0.21; P < 0.01). The relationship appeared to be more pronounced in newborns of nonallergic mothers (r = 0.24; P < 0.01) than in those of allergic mothers (r = 0.12). This could be due to the fact that familial history of allergy, the strongest determinant of IgE development, may overshadow the influence of lead on IgE in the offspring. Conclusions: Our findings suggest a possible intervention of environmental exposure besides genetic factors in early life development of IgE production. Further studies are needed to confirm the finding.

Original languageEnglish (US)
Pages (from-to)589-594
Number of pages6
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume58
Issue number7
DOIs
StatePublished - Jul 1 2003

Fingerprint

Fetal Blood
Immunoglobulin E
Hypersensitivity
Poisons
Environmental Exposure
Paris
Hair
Developing Countries
Parturition

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Annesi-Maesano, Isabella ; Pollitt, R. ; King, Gary ; Bousquet, J. ; Hellier, G. ; Sahuquillo, J. ; Huel, G. / In utero exposure to lead and cord blood total IgE. Is there a connection?. In: Allergy: European Journal of Allergy and Clinical Immunology. 2003 ; Vol. 58, No. 7. pp. 589-594.
@article{81589d2ef39a46de9f3310595457ea3c,
title = "In utero exposure to lead and cord blood total IgE. Is there a connection?",
abstract = "Background: Lead exposure and total immunoglobulin E (IgE) have been shown to be positively related in animals and humans even at lead levels below those recognized as toxic. In the last decades, exposure to lead has become more frequent in urban areas of industrialized as well as of developing countries where IgE-mediated allergy prevalence has also increased. Methods: We examined for the first time the relationship between in utero exposure to lead and cord blood total IgE in two samples of 137 and 237 mother-newborn pairs, respectively, recruited in Paris. Results: Cord blood IgE was positively related to hair lead level at birth, providing an integrated measure of long-term exposure in utero, in each cohort (Spearman's coefficient r = 0.32, P < 0.001 and r = 0.19, P < 0.01, respectively) and in the combined cohort (r = 0.21; P < 0.01). The relationship appeared to be more pronounced in newborns of nonallergic mothers (r = 0.24; P < 0.01) than in those of allergic mothers (r = 0.12). This could be due to the fact that familial history of allergy, the strongest determinant of IgE development, may overshadow the influence of lead on IgE in the offspring. Conclusions: Our findings suggest a possible intervention of environmental exposure besides genetic factors in early life development of IgE production. Further studies are needed to confirm the finding.",
author = "Isabella Annesi-Maesano and R. Pollitt and Gary King and J. Bousquet and G. Hellier and J. Sahuquillo and G. Huel",
year = "2003",
month = "7",
day = "1",
doi = "10.1034/j.1398-9995.2003.00111.x",
language = "English (US)",
volume = "58",
pages = "589--594",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley-Blackwell",
number = "7",

}

In utero exposure to lead and cord blood total IgE. Is there a connection? / Annesi-Maesano, Isabella; Pollitt, R.; King, Gary; Bousquet, J.; Hellier, G.; Sahuquillo, J.; Huel, G.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 58, No. 7, 01.07.2003, p. 589-594.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In utero exposure to lead and cord blood total IgE. Is there a connection?

AU - Annesi-Maesano, Isabella

AU - Pollitt, R.

AU - King, Gary

AU - Bousquet, J.

AU - Hellier, G.

AU - Sahuquillo, J.

AU - Huel, G.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Background: Lead exposure and total immunoglobulin E (IgE) have been shown to be positively related in animals and humans even at lead levels below those recognized as toxic. In the last decades, exposure to lead has become more frequent in urban areas of industrialized as well as of developing countries where IgE-mediated allergy prevalence has also increased. Methods: We examined for the first time the relationship between in utero exposure to lead and cord blood total IgE in two samples of 137 and 237 mother-newborn pairs, respectively, recruited in Paris. Results: Cord blood IgE was positively related to hair lead level at birth, providing an integrated measure of long-term exposure in utero, in each cohort (Spearman's coefficient r = 0.32, P < 0.001 and r = 0.19, P < 0.01, respectively) and in the combined cohort (r = 0.21; P < 0.01). The relationship appeared to be more pronounced in newborns of nonallergic mothers (r = 0.24; P < 0.01) than in those of allergic mothers (r = 0.12). This could be due to the fact that familial history of allergy, the strongest determinant of IgE development, may overshadow the influence of lead on IgE in the offspring. Conclusions: Our findings suggest a possible intervention of environmental exposure besides genetic factors in early life development of IgE production. Further studies are needed to confirm the finding.

AB - Background: Lead exposure and total immunoglobulin E (IgE) have been shown to be positively related in animals and humans even at lead levels below those recognized as toxic. In the last decades, exposure to lead has become more frequent in urban areas of industrialized as well as of developing countries where IgE-mediated allergy prevalence has also increased. Methods: We examined for the first time the relationship between in utero exposure to lead and cord blood total IgE in two samples of 137 and 237 mother-newborn pairs, respectively, recruited in Paris. Results: Cord blood IgE was positively related to hair lead level at birth, providing an integrated measure of long-term exposure in utero, in each cohort (Spearman's coefficient r = 0.32, P < 0.001 and r = 0.19, P < 0.01, respectively) and in the combined cohort (r = 0.21; P < 0.01). The relationship appeared to be more pronounced in newborns of nonallergic mothers (r = 0.24; P < 0.01) than in those of allergic mothers (r = 0.12). This could be due to the fact that familial history of allergy, the strongest determinant of IgE development, may overshadow the influence of lead on IgE in the offspring. Conclusions: Our findings suggest a possible intervention of environmental exposure besides genetic factors in early life development of IgE production. Further studies are needed to confirm the finding.

UR - http://www.scopus.com/inward/record.url?scp=0038575316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038575316&partnerID=8YFLogxK

U2 - 10.1034/j.1398-9995.2003.00111.x

DO - 10.1034/j.1398-9995.2003.00111.x

M3 - Article

C2 - 12823116

AN - SCOPUS:0038575316

VL - 58

SP - 589

EP - 594

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - 7

ER -