In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy

Ellen S. Moland, David W. Craft, Seong Geun Hong, Soo Young Kim, Lucas Hachmeister, Shimon D. Sayed, Kenneth S. Thomson

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Abstract

Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.

Original languageEnglish (US)
Pages (from-to)2940-2942
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number8
DOIs
StatePublished - Aug 1 2008

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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