In vitro activity studies of hyperthermal near-infrared nanoGUMBOS in MDA-MB-231 breast cancer cells

Jonathan C. Dumke, Ammar Qureshi, Suzana Hamdan, Kresimir Rupnik, Bilal El-Zahab, Daniel J. Hayes, Isiah M. Warner

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A new kind of material called nanoGUMBOS, comprised entirely of cations and anions, has been developed by pairing various functional ions that exhibit fluorescence activity with biocompatible ions, in a process very much akin to that employed in ionic liquid chemistry. In the present study, spectral and biological properties of NIR absorbing nanoGUMBOS were evaluated using electron microscopy, dynamic light scattering, absorbance, thermal imaging, and live/dead fluorescence assays in conjunction with malignant MDA-MB-231 and non-malignant HS-578-BST epithelial human breast cells. The primary focus of this study was to maximize heat generation using NIR laser irradiation and minimize non-specific cytotoxicity using biocompatible constituent ions (e.g. amino acids, vitamins, or organic acids). Concurrently, in order to generate highly responsive nanomaterials for NIR-laser-triggered hyperthermia, optimization of the nanoparticle size, shape, and uniformity was carried out. Evaluation of data from hyperthermal studies of NIR absorbing nanoGUMBOS shows that these materials can achieve temperatures above the threshold for killing cancerous cells. Additionally, in vitro cell based assays demonstrated their promising hyperthermal effects on cancer derived epithelial cells.

Original languageEnglish (US)
Pages (from-to)1270-1280
Number of pages11
JournalPhotochemical and Photobiological Sciences
Volume13
Issue number9
DOIs
StatePublished - Sep 2014

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multiple docking adapters
breast
cancer
Cells
Ions
Breast Neoplasms
Infrared radiation
Assays
Lasers
Hot Temperature
Fluorescence
cells
Ionic Liquids
vitamins
fluorescence
ions
Nanostructures
hyperthermia
heat generation
Organic acids

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Medicine(all)

Cite this

Dumke, Jonathan C. ; Qureshi, Ammar ; Hamdan, Suzana ; Rupnik, Kresimir ; El-Zahab, Bilal ; Hayes, Daniel J. ; Warner, Isiah M. / In vitro activity studies of hyperthermal near-infrared nanoGUMBOS in MDA-MB-231 breast cancer cells. In: Photochemical and Photobiological Sciences. 2014 ; Vol. 13, No. 9. pp. 1270-1280.
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In vitro activity studies of hyperthermal near-infrared nanoGUMBOS in MDA-MB-231 breast cancer cells. / Dumke, Jonathan C.; Qureshi, Ammar; Hamdan, Suzana; Rupnik, Kresimir; El-Zahab, Bilal; Hayes, Daniel J.; Warner, Isiah M.

In: Photochemical and Photobiological Sciences, Vol. 13, No. 9, 09.2014, p. 1270-1280.

Research output: Contribution to journalArticle

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