In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-α production by dimeric gallotannin analogues

Ken S. Feldman, Sarah L. Wilson, Michael D. Lawlor, Charles H. Lang, William J. Scheuchenzuber

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Designed dimeric gallotannin analogues featuring two tetragalloylglucopyranose cores connected by various hydrocarbon linkers inhibit tumor necrosis factor-α secretion from lipopolysaccharide-stimulated human peripheral blood mononuclear cells by up to 53% (5-24 μM concentration range) compared to control. Comparable suppression of tumor necrosis factor-α levels (∼50% vs control) was observed in the plasma of rats co-treated with lipopolysaccharide and specific tannin analogues selected for their lack of interleukin 1-β stimulating activity.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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