In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-α production by dimeric gallotannin analogues

Ken S. Feldman, Sarah L. Wilson, Michael D. Lawlor, Charles H. Lang, William J. Scheuchenzuber

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Designed dimeric gallotannin analogues featuring two tetragalloylglucopyranose cores connected by various hydrocarbon linkers inhibit tumor necrosis factor-α secretion from lipopolysaccharide-stimulated human peripheral blood mononuclear cells by up to 53% (5-24 μM concentration range) compared to control. Comparable suppression of tumor necrosis factor-α levels (∼50% vs control) was observed in the plasma of rats co-treated with lipopolysaccharide and specific tannin analogues selected for their lack of interleukin 1-β stimulating activity.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2002

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Hydrolyzable Tannins
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Tannins
Hydrocarbons
Interleukin-1
Rats
Blood Cells
Blood
Plasmas
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Feldman, Ken S. ; Wilson, Sarah L. ; Lawlor, Michael D. ; Lang, Charles H. ; Scheuchenzuber, William J. / In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-α production by dimeric gallotannin analogues. In: Bioorganic and Medicinal Chemistry. 2002 ; Vol. 10, No. 1. pp. 47-55.
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In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-α production by dimeric gallotannin analogues. / Feldman, Ken S.; Wilson, Sarah L.; Lawlor, Michael D.; Lang, Charles H.; Scheuchenzuber, William J.

In: Bioorganic and Medicinal Chemistry, Vol. 10, No. 1, 01.01.2002, p. 47-55.

Research output: Contribution to journalArticle

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