The naturally occurring gallotannin β-D-pentagalloylglucose (β-PGG) decreases tumor necrosis factor-alpha (TNF-α) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at ∼5 μM concentration. A qualitatively similar but less pronounced effect (∼50% decrease) was observed in the serum of rats dosed with both LPS and β-PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-α.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science