In vitro anti-malarial drug susceptibility of temperate Plasmodium vivax from central China

Feng Lu, Qi Gao, Kesinee Chotivanich, Hui Xia, Jun Cao, Rachanee Udomsangpetch, Liwang Cui, Jetsumon Sattabongkot

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15 Scopus citations

Abstract

In the face of recent increase of Plasmodium vivax malaria in central China, we conducted a study to evaluate in vitro susceptibility of temperate-zone P. vivax parasites to antimalarial drugs. During 2005-2006, in vitro drug susceptibility was measured for 42 clinical P. vivax isolates by using a schizont maturation inhibition technique. Geometric means of 50% inhibitory concentrations (IC50s) and 95% confidence intervals (CIs) were 10.87 (4.50-26.26) ng/mL for chloroquine, 4.21 (1.88-9.42-8) ng/mL for mefloquine, 11.82 (6.20-22.56) ng/mL for quinine, 0.13 (0.09-0.20) ng/mL for artesunate, 18.32 (8.08-41.50) ng/mL for pyrimethamine, and 17.73 (10.29-30.57) ng/mL for piperaquine. The IC50for chloroquine was lower than those obtained from isolates from Thailand and South Korea, suggesting that chloroquine remained effective against P. vivax malaria in central China. The results further indicated that temperate-zone P. vivax isolates from China were more susceptible to chloroquine, quinine, and mefloquine than isolates from Thailand.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume85
Issue number2
DOIs
StatePublished - Aug 2011

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Virology
  • Infectious Diseases

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