In vitro anti-malarial drug susceptibility of temperate Plasmodium vivax from central China

Feng Lu, Qi Gao, Kesinee Chotivanich, Hui Xia, Jun Cao, Rachanee Udomsangpetch, Liwang Cui, Jetsumon Sattabongkot

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In the face of recent increase of Plasmodium vivax malaria in central China, we conducted a study to evaluate in vitro susceptibility of temperate-zone P. vivax parasites to antimalarial drugs. During 2005-2006, in vitro drug susceptibility was measured for 42 clinical P. vivax isolates by using a schizont maturation inhibition technique. Geometric means of 50% inhibitory concentrations (IC50s) and 95% confidence intervals (CIs) were 10.87 (4.50-26.26) ng/mL for chloroquine, 4.21 (1.88-9.42-8) ng/mL for mefloquine, 11.82 (6.20-22.56) ng/mL for quinine, 0.13 (0.09-0.20) ng/mL for artesunate, 18.32 (8.08-41.50) ng/mL for pyrimethamine, and 17.73 (10.29-30.57) ng/mL for piperaquine. The IC50for chloroquine was lower than those obtained from isolates from Thailand and South Korea, suggesting that chloroquine remained effective against P. vivax malaria in central China. The results further indicated that temperate-zone P. vivax isolates from China were more susceptible to chloroquine, quinine, and mefloquine than isolates from Thailand.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume85
Issue number2
DOIs
StatePublished - Aug 1 2011

Fingerprint

Plasmodium vivax
Chloroquine
Antimalarials
China
Vivax Malaria
Mefloquine
Quinine
Thailand
Pharmaceutical Preparations
Schizonts
Pyrimethamine
Republic of Korea
Inhibitory Concentration 50
Parasites
Confidence Intervals
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Virology
  • Infectious Diseases

Cite this

Lu, Feng ; Gao, Qi ; Chotivanich, Kesinee ; Xia, Hui ; Cao, Jun ; Udomsangpetch, Rachanee ; Cui, Liwang ; Sattabongkot, Jetsumon. / In vitro anti-malarial drug susceptibility of temperate Plasmodium vivax from central China. In: American Journal of Tropical Medicine and Hygiene. 2011 ; Vol. 85, No. 2. pp. 197-201.
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Lu, F, Gao, Q, Chotivanich, K, Xia, H, Cao, J, Udomsangpetch, R, Cui, L & Sattabongkot, J 2011, 'In vitro anti-malarial drug susceptibility of temperate Plasmodium vivax from central China', American Journal of Tropical Medicine and Hygiene, vol. 85, no. 2, pp. 197-201. https://doi.org/10.4269/ajtmh.2011.10-0070

In vitro anti-malarial drug susceptibility of temperate Plasmodium vivax from central China. / Lu, Feng; Gao, Qi; Chotivanich, Kesinee; Xia, Hui; Cao, Jun; Udomsangpetch, Rachanee; Cui, Liwang; Sattabongkot, Jetsumon.

In: American Journal of Tropical Medicine and Hygiene, Vol. 85, No. 2, 01.08.2011, p. 197-201.

Research output: Contribution to journalArticle

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