In vitro evaluation of diopside/baghdadite bioceramic scaffolds modified by polycaprolactone fumarate polymer coating

Sorour Sadeghzade, Rahmatollah Emadi, Fariborz Tavangarian, Ali Doostmohammadi

Research output: Contribution to journalArticle

Abstract

Porous Si-based ceramic scaffolds are widely attracted in biomedical tissue engineering application. Despite the attractive properties of these materials, their weak mechanical properties and high degradability in vitro and in vivo environment can limit their application as biomedical devises. Applying a thin layer of polymer on the surface of porous scaffolds can improve the mechanical properties and control the degradation rate. In this study, we produced new modified scaffolds with polymers coating in order to improved mechanical and biological properties of Si-based ceramics scaffolds. The results showed that applying 6 wt% PCLF polymer on the surface of Bagh-15 wt%Dio scaffolds delayed apatite formation compared to unmodified scaffolds. On the other hand, in the modified scaffolds, apatite formation was observed. The degradation rate of unmodified scaffolds was decreased around 82% after 28 days soaking in PBS solution. Based on the MTT assay and SEM micrographs, the BMS cells were spread and attached well on the surface of the scaffolds, which indicated a good biocompatibility. The results showed that these scaffolds have the potential to be used as a temporary substrate for bone tissue engineering application.

Original languageEnglish (US)
Article number110176
JournalMaterials Science and Engineering C
Volume106
DOIs
StatePublished - Jan 1 2020

Fingerprint

Bioceramics
Polycaprolactone
Scaffolds
Polymers
tissue engineering
mechanical properties
apatites
coatings
Coatings
evaluation
polymers
ceramics
degradation
Scaffolds (biology)
soaking
Apatites
biocompatibility
Apatite
bones
Tissue engineering

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

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title = "In vitro evaluation of diopside/baghdadite bioceramic scaffolds modified by polycaprolactone fumarate polymer coating",
abstract = "Porous Si-based ceramic scaffolds are widely attracted in biomedical tissue engineering application. Despite the attractive properties of these materials, their weak mechanical properties and high degradability in vitro and in vivo environment can limit their application as biomedical devises. Applying a thin layer of polymer on the surface of porous scaffolds can improve the mechanical properties and control the degradation rate. In this study, we produced new modified scaffolds with polymers coating in order to improved mechanical and biological properties of Si-based ceramics scaffolds. The results showed that applying 6 wt{\%} PCLF polymer on the surface of Bagh-15 wt{\%}Dio scaffolds delayed apatite formation compared to unmodified scaffolds. On the other hand, in the modified scaffolds, apatite formation was observed. The degradation rate of unmodified scaffolds was decreased around 82{\%} after 28 days soaking in PBS solution. Based on the MTT assay and SEM micrographs, the BMS cells were spread and attached well on the surface of the scaffolds, which indicated a good biocompatibility. The results showed that these scaffolds have the potential to be used as a temporary substrate for bone tissue engineering application.",
author = "Sorour Sadeghzade and Rahmatollah Emadi and Fariborz Tavangarian and Ali Doostmohammadi",
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In vitro evaluation of diopside/baghdadite bioceramic scaffolds modified by polycaprolactone fumarate polymer coating. / Sadeghzade, Sorour; Emadi, Rahmatollah; Tavangarian, Fariborz; Doostmohammadi, Ali.

In: Materials Science and Engineering C, Vol. 106, 110176, 01.01.2020.

Research output: Contribution to journalArticle

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T1 - In vitro evaluation of diopside/baghdadite bioceramic scaffolds modified by polycaprolactone fumarate polymer coating

AU - Sadeghzade, Sorour

AU - Emadi, Rahmatollah

AU - Tavangarian, Fariborz

AU - Doostmohammadi, Ali

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Porous Si-based ceramic scaffolds are widely attracted in biomedical tissue engineering application. Despite the attractive properties of these materials, their weak mechanical properties and high degradability in vitro and in vivo environment can limit their application as biomedical devises. Applying a thin layer of polymer on the surface of porous scaffolds can improve the mechanical properties and control the degradation rate. In this study, we produced new modified scaffolds with polymers coating in order to improved mechanical and biological properties of Si-based ceramics scaffolds. The results showed that applying 6 wt% PCLF polymer on the surface of Bagh-15 wt%Dio scaffolds delayed apatite formation compared to unmodified scaffolds. On the other hand, in the modified scaffolds, apatite formation was observed. The degradation rate of unmodified scaffolds was decreased around 82% after 28 days soaking in PBS solution. Based on the MTT assay and SEM micrographs, the BMS cells were spread and attached well on the surface of the scaffolds, which indicated a good biocompatibility. The results showed that these scaffolds have the potential to be used as a temporary substrate for bone tissue engineering application.

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