In vitro growth inhibition of human cancer cells by novel honokiol analogs

Jyh ming Lin, A. S. Prakasha Gowda, Arun Sharma, Shantu Amin

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Honokiol possesses many pharmacological activities including anti-cancer properties. Here in, we designed and synthesized honokiol analogs that block major honokiol metabolic pathway which may enhance their effectiveness. We studied their cytotoxicity in human cancer cells and evaluated possible mechanism of cell cycle arrest. Two analogs, namely 2 and 4, showed much higher growth inhibitory activity in A549 human lung cancer cells and significant increase of cell population in the G0-G1 phase. Further elucidation of the inhibition mechanism on cell cycle showed that analogs 2 and 4 inhibit both CDK1 and cyclin B1 protien levels in A549 cells.

Original languageEnglish (US)
Pages (from-to)3202-3211
Number of pages10
JournalBioorganic and Medicinal Chemistry
Volume20
Issue number10
DOIs
StatePublished - May 15 2012

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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