In Vitro Optogenetic Characterization of Neuropeptide Release from Prefrontal Cortical Somatostatin Neurons

Nigel C. Dao, Dakota F. Brockway, Nicole A. Crowley

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Somatostatin is a neuropeptide thought to play a role in a variety of neuropsychiatric disorders, and is important for healthy aging and behavioral resiliency. Physiological conditions underlying somatostatin peptidergic release are not well-defined. Using a combination of optogenetic and biochemical approaches in transgenic mice, we demonstrate an assay for the induction and inhibition of somatostatin release in mouse acute brain slices.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNeuroscience
Volume419
DOIs
StatePublished - Nov 1 2019

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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