In Vitro Performance Analysis of a Novel Pulsatile Diagonal Pump in a Simulated Pediatric Mechanical Circulatory Support System

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Abstract

The objective of this study was to evaluate the pump performance of the third-generation Medos diagonal pump, the Deltastream DP3, on hemodynamic profile and pulsatility in a simulated pediatric mechanical circulatory support (MCS) system. The experimental circuit consisted of a Medos Deltastream DP3 pump head and console (MEDOS Medizintechnik AG, Stolberg, Germany), a 14-Fr Terumo TenderFlow Pediatric arterial cannula and a 20-Fr Terumo TenderFlow Pediatric venous return cannula (Terumo Corporation, Tokyo, Japan), and 3ft of tubing with an internal diameter ofin. for both arterial and venous lines. Trials were conducted at flow rates ranging from 250mL/min to 1000mL/min (250-mL/min increments) and rotational speeds ranging from 1000 to 4000rpm (1000-rpm increments) using human blood (hematocrit 40%). The postcannula pressure was maintained at 60mmHg by a Hoffman clamp. Real-time pressure and flow data were recorded using a Labview-based acquisition system. The pump provided adequate nonpulsatile and pulsatile flow, created more hemodynamic energy under pulsatile mode, and generated higher positive and negative pressures when the inlet and outlet of the pump head, respectively, were clamped. After the conversion from nonpulsatile to pulsatile mode, the flow rates and the rotational speeds increased. In conclusion, the novel Medos Deltastream DP3 diagonal pump is able to supply the required flow rate for pediatric MCS, generate adequate quality of pulsatility, and provide surplus hemodynamic energy output in a simulated pediatric MCS system.

Original languageEnglish (US)
Pages (from-to)64-72
Number of pages9
JournalArtificial organs
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2014

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Pediatrics
Cardiovascular System
Pumps
Hemodynamics
Pulsatile Flow
Flow rate
Head
Pressure
Vascular Access Devices
Tokyo
Pulsatile flow
Hematocrit
Clamping devices
Germany
Tubing
Japan
In Vitro Techniques
Blood
Networks (circuits)
Industry

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

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abstract = "The objective of this study was to evaluate the pump performance of the third-generation Medos diagonal pump, the Deltastream DP3, on hemodynamic profile and pulsatility in a simulated pediatric mechanical circulatory support (MCS) system. The experimental circuit consisted of a Medos Deltastream DP3 pump head and console (MEDOS Medizintechnik AG, Stolberg, Germany), a 14-Fr Terumo TenderFlow Pediatric arterial cannula and a 20-Fr Terumo TenderFlow Pediatric venous return cannula (Terumo Corporation, Tokyo, Japan), and 3ft of tubing with an internal diameter ofin. for both arterial and venous lines. Trials were conducted at flow rates ranging from 250mL/min to 1000mL/min (250-mL/min increments) and rotational speeds ranging from 1000 to 4000rpm (1000-rpm increments) using human blood (hematocrit 40{\%}). The postcannula pressure was maintained at 60mmHg by a Hoffman clamp. Real-time pressure and flow data were recorded using a Labview-based acquisition system. The pump provided adequate nonpulsatile and pulsatile flow, created more hemodynamic energy under pulsatile mode, and generated higher positive and negative pressures when the inlet and outlet of the pump head, respectively, were clamped. After the conversion from nonpulsatile to pulsatile mode, the flow rates and the rotational speeds increased. In conclusion, the novel Medos Deltastream DP3 diagonal pump is able to supply the required flow rate for pediatric MCS, generate adequate quality of pulsatility, and provide surplus hemodynamic energy output in a simulated pediatric MCS system.",
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AB - The objective of this study was to evaluate the pump performance of the third-generation Medos diagonal pump, the Deltastream DP3, on hemodynamic profile and pulsatility in a simulated pediatric mechanical circulatory support (MCS) system. The experimental circuit consisted of a Medos Deltastream DP3 pump head and console (MEDOS Medizintechnik AG, Stolberg, Germany), a 14-Fr Terumo TenderFlow Pediatric arterial cannula and a 20-Fr Terumo TenderFlow Pediatric venous return cannula (Terumo Corporation, Tokyo, Japan), and 3ft of tubing with an internal diameter ofin. for both arterial and venous lines. Trials were conducted at flow rates ranging from 250mL/min to 1000mL/min (250-mL/min increments) and rotational speeds ranging from 1000 to 4000rpm (1000-rpm increments) using human blood (hematocrit 40%). The postcannula pressure was maintained at 60mmHg by a Hoffman clamp. Real-time pressure and flow data were recorded using a Labview-based acquisition system. The pump provided adequate nonpulsatile and pulsatile flow, created more hemodynamic energy under pulsatile mode, and generated higher positive and negative pressures when the inlet and outlet of the pump head, respectively, were clamped. After the conversion from nonpulsatile to pulsatile mode, the flow rates and the rotational speeds increased. In conclusion, the novel Medos Deltastream DP3 diagonal pump is able to supply the required flow rate for pediatric MCS, generate adequate quality of pulsatility, and provide surplus hemodynamic energy output in a simulated pediatric MCS system.

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