In vitro quantification of time dependent thrombus size using magnetic resonance imaging and computational simulations of thrombus surface shear stresses

Joshua O. Taylor, Kory P. Witmer, Thomas Neuberger, Brent A. Craven, Richard S. Meyer, Steven Deutsch, Keefe B. Manning

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Thrombosis and thromboembolization remain large obstacles in the design of cardiovascular devices. In this study, the temporal behavior of thrombus size within a backward-facing step (BFS) model is investigated, as this geometry can mimic the flow separation which has been found to contribute to thrombosis in cardiac devices. Magnetic resonance imaging (MRI) is used to quantify thrombus size and collect topographic data of thrombi formed by circulating bovine blood through a BFS model for times ranging between 10 and 90min at a constant upstream Reynolds number of 490. Thrombus height, length, exposed surface area, and volume are measured, and asymptotic behavior is observed for each as the blood circulation time is increased. Velocity patterns near, and wall shear stress (WSS) distributions on, the exposed thrombus surfaces are calculated using computational fluid dynamics (CFD). Both the mean and maximum WSS on the exposed thrombus surfaces are much more dependent on thrombus topography than thrombus size, and the best predictors for asymptotic thrombus length and volume are the reattachment length and volume of reversed flow, respectively, from the region of separated flow downstream of the BFS.

Original languageEnglish (US)
Article number071012
JournalJournal of Biomechanical Engineering
Volume136
Issue number7
DOIs
StatePublished - Jan 1 2014

Fingerprint

Magnetic resonance
Shear stress
Thrombosis
Magnetic Resonance Imaging
Imaging techniques
Flow separation
Hemodynamics
Magnetic resonance imaging
Topography
Stress concentration
Computational fluid dynamics
Reynolds number
Blood
Geometry
Blood Circulation Time
In Vitro Techniques
Equipment Design
Hydrodynamics
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Physiology (medical)

Cite this

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abstract = "Thrombosis and thromboembolization remain large obstacles in the design of cardiovascular devices. In this study, the temporal behavior of thrombus size within a backward-facing step (BFS) model is investigated, as this geometry can mimic the flow separation which has been found to contribute to thrombosis in cardiac devices. Magnetic resonance imaging (MRI) is used to quantify thrombus size and collect topographic data of thrombi formed by circulating bovine blood through a BFS model for times ranging between 10 and 90min at a constant upstream Reynolds number of 490. Thrombus height, length, exposed surface area, and volume are measured, and asymptotic behavior is observed for each as the blood circulation time is increased. Velocity patterns near, and wall shear stress (WSS) distributions on, the exposed thrombus surfaces are calculated using computational fluid dynamics (CFD). Both the mean and maximum WSS on the exposed thrombus surfaces are much more dependent on thrombus topography than thrombus size, and the best predictors for asymptotic thrombus length and volume are the reattachment length and volume of reversed flow, respectively, from the region of separated flow downstream of the BFS.",
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In vitro quantification of time dependent thrombus size using magnetic resonance imaging and computational simulations of thrombus surface shear stresses. / Taylor, Joshua O.; Witmer, Kory P.; Neuberger, Thomas; Craven, Brent A.; Meyer, Richard S.; Deutsch, Steven; Manning, Keefe B.

In: Journal of Biomechanical Engineering, Vol. 136, No. 7, 071012, 01.01.2014.

Research output: Contribution to journalArticle

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