In vitro studies on ultrasmall superparamagnetic iron oxide nanoparticles coated with gummic acid for T2 MRI contrast agent

I. Rabias, H. Pratsinis, G. Drossopoulou, M. Fardis, T. Maris, N. Boukos, Nikolaos Tsotakos, D. Kletsas, E. Tsilibary, G. Papavassiliou

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Ultrasmall superparamagnetic iron oxide nanoparticles coated with gummic acid have been investigated as possible constituents of aqueous ferrofluids for biomedical applications and especially for MRI contrast agent. The structural characteristics and the size of the nanoparticles have been analyzed as well as the magnetic properties. In order to evaluate any possible capabilities as a contrast agent, the relaxation time, T2, of hydrogen protons in the colloidal solutions of nanoparticles have been measured in order to gain information on the relaxation behavior compared to other MRI contrast agents. The in vitro cytotoxicity of the obtained magnetic nanoparticles of iron oxide coated with gummic acid was investigated by two separate methods (MTT and FACS analysis) and by using three different normal and transformed cell lines. Our results showed that the synthesized nanoparticles had no toxic effect on any of the cell lines used.

Original languageEnglish (US)
Article number044104
JournalBiomicrofluidics
Volume1
Issue number4
DOIs
StatePublished - Jan 1 2007

Fingerprint

Iron oxides
iron oxides
Nanoparticles
Magnetic resonance imaging
Contrast Media
nanoparticles
acids
Acids
cultured cells
Cells
Transformed Cell Line
Magnetic fluids
ferrofluids
Poisons
Cytotoxicity
Relaxation time
Protons
Hydrogen
Magnetic properties
relaxation time

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Materials Science(all)
  • Genetics
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

Rabias, I., Pratsinis, H., Drossopoulou, G., Fardis, M., Maris, T., Boukos, N., ... Papavassiliou, G. (2007). In vitro studies on ultrasmall superparamagnetic iron oxide nanoparticles coated with gummic acid for T2 MRI contrast agent. Biomicrofluidics, 1(4), [044104]. https://doi.org/10.1063/1.2821757
Rabias, I. ; Pratsinis, H. ; Drossopoulou, G. ; Fardis, M. ; Maris, T. ; Boukos, N. ; Tsotakos, Nikolaos ; Kletsas, D. ; Tsilibary, E. ; Papavassiliou, G. / In vitro studies on ultrasmall superparamagnetic iron oxide nanoparticles coated with gummic acid for T2 MRI contrast agent. In: Biomicrofluidics. 2007 ; Vol. 1, No. 4.
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Rabias, I, Pratsinis, H, Drossopoulou, G, Fardis, M, Maris, T, Boukos, N, Tsotakos, N, Kletsas, D, Tsilibary, E & Papavassiliou, G 2007, 'In vitro studies on ultrasmall superparamagnetic iron oxide nanoparticles coated with gummic acid for T2 MRI contrast agent', Biomicrofluidics, vol. 1, no. 4, 044104. https://doi.org/10.1063/1.2821757

In vitro studies on ultrasmall superparamagnetic iron oxide nanoparticles coated with gummic acid for T2 MRI contrast agent. / Rabias, I.; Pratsinis, H.; Drossopoulou, G.; Fardis, M.; Maris, T.; Boukos, N.; Tsotakos, Nikolaos; Kletsas, D.; Tsilibary, E.; Papavassiliou, G.

In: Biomicrofluidics, Vol. 1, No. 4, 044104, 01.01.2007.

Research output: Contribution to journalArticle

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AU - Rabias, I.

AU - Pratsinis, H.

AU - Drossopoulou, G.

AU - Fardis, M.

AU - Maris, T.

AU - Boukos, N.

AU - Tsotakos, Nikolaos

AU - Kletsas, D.

AU - Tsilibary, E.

AU - Papavassiliou, G.

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