In vivo glucose utilization by individual tissues during nonlethal hypermetabolic sepsis

K. Meszaros, C. H. Lang, G. J. Bagby, J. J. Spitzer

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Febrile sepsis was induced in rats by repeated s.c. injections of live Escherichia coli bacteria. Glucose utilization of different tissues was investigated in vivo by using the 2-deoxyglucose tracer technique. In septic rats the rate of glucose utilization was increased in macrophage-rich tissues, including the liver (2.7-fold), spleen (2.4-fold, and ileum (1.6-fold), compared with tissues from time-matched nonseptic animals. A smaller increase in glucose utilization was evident in the abdominal muscle (1.3-fold) and in the white portion of the quadriceps muscle (1.3-fold). Changes were not significant in nine other tissues, including the brain. We postulate that in sepsis the mononuclear phagocyte system may be responsible for most of the increment of glucose utilization, and the latter provides metabolic support for the increased antibacterial activity of these cells.

Original languageEnglish (US)
Pages (from-to)3083-3086
Number of pages4
JournalFASEB Journal
Volume2
Issue number15
StatePublished - Dec 1 1988

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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