In vivo observation of cavitation on prosthetic heart valves

Conrad M. Zapanta, David R. Stinebring, Deborah S. Sneckenberger, Steven Deutsch, David B. Geselowitz, John M. Tarbell, Alan J. Snyder, Gerson Rosenberg, William Weiss, Walter Pae, William S. Pierce

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In this study, a method to determine the existence of prosthetic heart valve cavitation in vivo is presented. Pennsylvania State University Left Ventricular Assist Devices (LVADs) were implanted in two separate calves for this study. Bjork-Shiley Monostrut (Irvine, CA) 27 mm and 25 mm valves with Delrin occluders were used in the mitral and aortic positions, respectively. A high fidelity, piezoelectric pressure transducer was mounted approximately 1.25 cm proximal to the mitral valve and measured the high frequency pressure fluctuations caused by cavitation bubble formation and collapse after valve closure. The root mean square (RMS) value of the mitral pressure signal during a 5 ms interval after valve closure was used as a measure of cavitation intensity. The pressure signals observed in vivo were similar to ones observed in vitro with the same type of pressure transducer and were associated with the visually observed cavitation. The percentage of beats with cavitation increased from 20.3% to 67.7% when pump filling was decreased by increasing beat rate. A blood test conducted during post-operative days 1- 3 showed a significant increase in plasma hemoglobin during the low filling condition. However, blood tests conducted later (post-operative days 7-44) did not show a significant change in plasma hemoglobin during low filling conditions.

Original languageEnglish (US)
JournalASAIO Journal
Volume42
Issue number5
StatePublished - Sep 1 1996

Fingerprint

Heart valve prostheses
Heart Valves
Cavitation
Pressure Transducers
Observation
Hematologic Tests
Pressure
Hemoglobins
Pressure transducers
Hemoglobin
Heart-Assist Devices
Mitral Valve
Blood
Left ventricular assist devices
Plasmas
Bubble formation
Piezoelectric transducers
Pumps

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Zapanta, C. M., Stinebring, D. R., Sneckenberger, D. S., Deutsch, S., Geselowitz, D. B., Tarbell, J. M., ... Pierce, W. S. (1996). In vivo observation of cavitation on prosthetic heart valves. ASAIO Journal, 42(5).
Zapanta, Conrad M. ; Stinebring, David R. ; Sneckenberger, Deborah S. ; Deutsch, Steven ; Geselowitz, David B. ; Tarbell, John M. ; Snyder, Alan J. ; Rosenberg, Gerson ; Weiss, William ; Pae, Walter ; Pierce, William S. / In vivo observation of cavitation on prosthetic heart valves. In: ASAIO Journal. 1996 ; Vol. 42, No. 5.
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Zapanta, CM, Stinebring, DR, Sneckenberger, DS, Deutsch, S, Geselowitz, DB, Tarbell, JM, Snyder, AJ, Rosenberg, G, Weiss, W, Pae, W & Pierce, WS 1996, 'In vivo observation of cavitation on prosthetic heart valves', ASAIO Journal, vol. 42, no. 5.

In vivo observation of cavitation on prosthetic heart valves. / Zapanta, Conrad M.; Stinebring, David R.; Sneckenberger, Deborah S.; Deutsch, Steven; Geselowitz, David B.; Tarbell, John M.; Snyder, Alan J.; Rosenberg, Gerson; Weiss, William; Pae, Walter; Pierce, William S.

In: ASAIO Journal, Vol. 42, No. 5, 01.09.1996.

Research output: Contribution to journalArticle

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AU - Zapanta, Conrad M.

AU - Stinebring, David R.

AU - Sneckenberger, Deborah S.

AU - Deutsch, Steven

AU - Geselowitz, David B.

AU - Tarbell, John M.

AU - Snyder, Alan J.

AU - Rosenberg, Gerson

AU - Weiss, William

AU - Pae, Walter

AU - Pierce, William S.

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Y1 - 1996/9/1

N2 - In this study, a method to determine the existence of prosthetic heart valve cavitation in vivo is presented. Pennsylvania State University Left Ventricular Assist Devices (LVADs) were implanted in two separate calves for this study. Bjork-Shiley Monostrut (Irvine, CA) 27 mm and 25 mm valves with Delrin occluders were used in the mitral and aortic positions, respectively. A high fidelity, piezoelectric pressure transducer was mounted approximately 1.25 cm proximal to the mitral valve and measured the high frequency pressure fluctuations caused by cavitation bubble formation and collapse after valve closure. The root mean square (RMS) value of the mitral pressure signal during a 5 ms interval after valve closure was used as a measure of cavitation intensity. The pressure signals observed in vivo were similar to ones observed in vitro with the same type of pressure transducer and were associated with the visually observed cavitation. The percentage of beats with cavitation increased from 20.3% to 67.7% when pump filling was decreased by increasing beat rate. A blood test conducted during post-operative days 1- 3 showed a significant increase in plasma hemoglobin during the low filling condition. However, blood tests conducted later (post-operative days 7-44) did not show a significant change in plasma hemoglobin during low filling conditions.

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Zapanta CM, Stinebring DR, Sneckenberger DS, Deutsch S, Geselowitz DB, Tarbell JM et al. In vivo observation of cavitation on prosthetic heart valves. ASAIO Journal. 1996 Sep 1;42(5).