In vivo testing of a completely implanted total artificial heart system

A. J. Snyder, G. Rosenberg, W. J. Weiss, S. K. Ford, R. A. Nazarian, D. L. Hicks, J. A. Marlotte, O. Kawaguchi, G. A. Prophet, J. S. Sapirstein, M. Schwartz, W. S. Pierce

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The authors performed 14 implants of a completely implanted total artificial heart (TAH) system in calves. The system consisted of a dual pusher plate rollerscrew energy converter, two sac type blood pumps, an implanted electronic control and battery package, and a transcutaneous energy transmission system. Ten of the implants included a percutaneous lead for monitoring of the implant; the remainder made use of wireless two way telemetry between the implant and the outside. Three animals survived the perioperative period. These calves survived for 98 to 118 days, and one was still alive at 150 days. Causes for termination of the 98 and 118 day cases were abdominal pocket sepsis originating at a monitoring line, and systemic sepsis acquired perioperatively. Death or termination in the shorter cases was mainly due to respiratory complications or bleeding. The TAH system proved capable of providing adequate cardiac outputs at modest atrial pressures. Wireless monitoring and wireless intervention for weaning from cardiopulmonary bypass were readily achieved. All organ systems functioned normally in the presence of the device. Once recovery from implantation in these very young animals was achieved, the system proved its ability to reliably support these animals until body mass exceeded its cardiac output capabilities.

Original languageEnglish (US)
Pages (from-to)M177-M184
JournalASAIO Journal
Volume39
Issue number3
DOIs
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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