In vivo upregulation of interleukin-4 is one mechanism underlying the immunoregulatory effects of 1,25-dihydroxyvitamin D3 1

Margherita Teresa-Anna Cantorna, Jean Humpal-Winter, Hector F. DeLuca

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The active form of vitamin D (1,25-(OH)2D3) is a potent immune system regulator. In vivo the oral administration of 1,25-(OH)2D3 completely prevents experimental autoimmune encephalomyelitis (EAE), significantly prolongs allograft survival, and prevents collagen-induced arthritis. 1,25- (OH)2D3 given to mice increased IL-4 protein and transcript levels. We have now tested the efficacy of 1,25-(OH)2D3 on EAE development and allograft survival in IL-4-deficient [knockout (ko)] mice. 1,25-(OH)2D3 was found to be much less effective in the absence of IL-4, suggesting that IL-4 production is a significant factor in the action of 1,25-(OH)2D3 on the immune system. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalArchives of Biochemistry and Biophysics
Volume377
Issue number1
DOIs
StatePublished - May 1 2000

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology

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