Inability of serum myocyte death markers to predict acute cardiac allograft rejection

Chao Wen Wang, Steven R. Steinhubl, William J. Castellani, Frederick Van Lente, Dave P. Miller, Karen B. James, James B. Young

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Acute cardiac rejection involves myocyte necrosis. Hence, markers of myocyte death may be useful in diagnosing rejection. Creatine kinase MB, MB isoforms, and troponins I and T were measured in 186 patients undergoing 365 endomyocardial biopsies. No differences were noted with rejection (rejectors vs. nonrejectors: CK=63.8 U/L and 86.6 U/L, P=0.0881; CK MB=2.04 ng/ml and 2.06 ng/ml, P=0.949; troponin T=0.134 ng/ml and 0.0881 ng/ml, P=0.374; troponin I=0.216 ng/ml and 0.707 ng/ml, P=0.357). The time course of troponins T and I levels in rejectors and nonrejectors do not differ with both groups having early elevations. Markers of myocyte death are inadequate predictors of acute rejection in cardiac allografts. The time course of troponins T and I suggests a possible role as prognostic indicators of outcome.

Original languageEnglish (US)
Pages (from-to)1938-1941
Number of pages4
JournalTransplantation
Volume62
Issue number12
DOIs
StatePublished - Dec 27 1996

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Troponin T
Troponin I
Muscle Cells
Allografts
Serum
MB Form Creatine Kinase
Protein Isoforms
Necrosis
Biopsy

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Wang, C. W., Steinhubl, S. R., Castellani, W. J., Van Lente, F., Miller, D. P., James, K. B., & Young, J. B. (1996). Inability of serum myocyte death markers to predict acute cardiac allograft rejection. Transplantation, 62(12), 1938-1941. https://doi.org/10.1097/00007890-199612270-00046
Wang, Chao Wen ; Steinhubl, Steven R. ; Castellani, William J. ; Van Lente, Frederick ; Miller, Dave P. ; James, Karen B. ; Young, James B. / Inability of serum myocyte death markers to predict acute cardiac allograft rejection. In: Transplantation. 1996 ; Vol. 62, No. 12. pp. 1938-1941.
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Wang, CW, Steinhubl, SR, Castellani, WJ, Van Lente, F, Miller, DP, James, KB & Young, JB 1996, 'Inability of serum myocyte death markers to predict acute cardiac allograft rejection', Transplantation, vol. 62, no. 12, pp. 1938-1941. https://doi.org/10.1097/00007890-199612270-00046

Inability of serum myocyte death markers to predict acute cardiac allograft rejection. / Wang, Chao Wen; Steinhubl, Steven R.; Castellani, William J.; Van Lente, Frederick; Miller, Dave P.; James, Karen B.; Young, James B.

In: Transplantation, Vol. 62, No. 12, 27.12.1996, p. 1938-1941.

Research output: Contribution to journalArticle

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AU - Castellani, William J.

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AU - Miller, Dave P.

AU - James, Karen B.

AU - Young, James B.

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N2 - Acute cardiac rejection involves myocyte necrosis. Hence, markers of myocyte death may be useful in diagnosing rejection. Creatine kinase MB, MB isoforms, and troponins I and T were measured in 186 patients undergoing 365 endomyocardial biopsies. No differences were noted with rejection (rejectors vs. nonrejectors: CK=63.8 U/L and 86.6 U/L, P=0.0881; CK MB=2.04 ng/ml and 2.06 ng/ml, P=0.949; troponin T=0.134 ng/ml and 0.0881 ng/ml, P=0.374; troponin I=0.216 ng/ml and 0.707 ng/ml, P=0.357). The time course of troponins T and I levels in rejectors and nonrejectors do not differ with both groups having early elevations. Markers of myocyte death are inadequate predictors of acute rejection in cardiac allografts. The time course of troponins T and I suggests a possible role as prognostic indicators of outcome.

AB - Acute cardiac rejection involves myocyte necrosis. Hence, markers of myocyte death may be useful in diagnosing rejection. Creatine kinase MB, MB isoforms, and troponins I and T were measured in 186 patients undergoing 365 endomyocardial biopsies. No differences were noted with rejection (rejectors vs. nonrejectors: CK=63.8 U/L and 86.6 U/L, P=0.0881; CK MB=2.04 ng/ml and 2.06 ng/ml, P=0.949; troponin T=0.134 ng/ml and 0.0881 ng/ml, P=0.374; troponin I=0.216 ng/ml and 0.707 ng/ml, P=0.357). The time course of troponins T and I levels in rejectors and nonrejectors do not differ with both groups having early elevations. Markers of myocyte death are inadequate predictors of acute rejection in cardiac allografts. The time course of troponins T and I suggests a possible role as prognostic indicators of outcome.

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Wang CW, Steinhubl SR, Castellani WJ, Van Lente F, Miller DP, James KB et al. Inability of serum myocyte death markers to predict acute cardiac allograft rejection. Transplantation. 1996 Dec 27;62(12):1938-1941. https://doi.org/10.1097/00007890-199612270-00046