Inability of serum myocyte death markers to predict acute cardiac allograft rejection

Chao Wen Wang, Steven R. Steinhubl, William J. Castellani, Frederick Van Lente, Dave P. Miller, Karen B. James, James B. Young

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Acute cardiac rejection involves myocyte necrosis. Hence, markers of myocyte death may be useful in diagnosing rejection. Creatine kinase MB, MB isoforms, and troponins I and T were measured in 186 patients undergoing 365 endomyocardial biopsies. No differences were noted with rejection (rejectors vs. nonrejectors: CK=63.8 U/L and 86.6 U/L, P=0.0881; CK MB=2.04 ng/ml and 2.06 ng/ml, P=0.949; troponin T=0.134 ng/ml and 0.0881 ng/ml, P=0.374; troponin I=0.216 ng/ml and 0.707 ng/ml, P=0.357). The time course of troponins T and I levels in rejectors and nonrejectors do not differ with both groups having early elevations. Markers of myocyte death are inadequate predictors of acute rejection in cardiac allografts. The time course of troponins T and I suggests a possible role as prognostic indicators of outcome.

Original languageEnglish (US)
Pages (from-to)1938-1941
Number of pages4
JournalTransplantation
Volume62
Issue number12
DOIs
StatePublished - Dec 27 1996

All Science Journal Classification (ASJC) codes

  • Transplantation

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