Inactivation of the bacterial RNA polymerase due to acquisition of secondary structure by theω subunit

Paramita Sarkar, Abhijit A. Sardesai, Katsuhiko S. Murakami, Dipankar Chatterji

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Although universally conserved, ω is the only nonessential subunit of RNA polymerase, and its function is mostly undetermined. Results: Dominant lethal mutants of ω were isolated and analyzed genetically and biochemically. Conclusion: Mutations in ω that alter its structure interfere with RNA polymerase catalytic properties. Significance: Results suggest a critical role for ω during transcription, bypassing the effects of compensatory proteins.

Original languageEnglish (US)
Pages (from-to)25076-25087
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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