Incidence and treatment of rejection episodes in primary orthotopic liver transplantation under FK 506

Ashokkumar Jain, J. J. Fung, S. Todo, M. Alessiani, S. Takaya, K. Abu-Elmagd, A. Tzakis, T. E. Starzl

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Abstract

FK 506 therapy with low doses of steroids was adequate to control rejection in most liver recipients. Rejection episodes were readily reversed with single IV doses of methylprednisone or hydrocortisone. Short courses of OKT3 (3 to 5 days 5-10 mL) controlled severe rejections. The rate of retransplantation directly due to rejection was low (1.6%). There was a limited need for steroids either early or out to 6 to 12 months.

Original languageEnglish (US)
Pages (from-to)928-930
Number of pages3
JournalTransplantation Proceedings
Volume23
Issue number1 II
Publication statusPublished - Mar 13 1991

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

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Jain, A., Fung, J. J., Todo, S., Alessiani, M., Takaya, S., Abu-Elmagd, K., ... Starzl, T. E. (1991). Incidence and treatment of rejection episodes in primary orthotopic liver transplantation under FK 506. Transplantation Proceedings, 23(1 II), 928-930.