Incidence of late atrial fibrillation in bilateral lung versus heart transplants

J. Trent Magruder, William Plum, Todd C. Crawford, Joshua C. Grimm, Marvin C. Borja, Ronald D. Berger, Harikrishna Tandri, Hugh Calkins, Duke E. Cameron, Kaushik Mandal

Research output: Contribution to journalArticle

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Abstract

Background We compared the incidence of late-onset atrial fibrillation in orthotopic heart transplant recipients and bilateral orthotopic lung transplant recipients. Methods We reviewed the records of all heart and lung transplant operations carried out in our institution between 1995 and 2015. We performed 1:1 propensity-matching based on patient age, sex, body mass index, and hypertension. Our primary outcome, late-onset atrial fibrillation, was defined as atrial fibrillation occurring after discharge following hospitalization for transplantation. Results Over the study period, 397 orthotopic heart transplants and 240 bilateral orthotopic lung transplants were performed. Propensity matching resulted in 173 pairs who were matched with respect to age, sex, body mass index, and preoperative hypertension. The median follow-up was 5.3 years for heart transplant patients and 3.1 years for lung transplant patients. Late-onset atrial fibrillation occurred in 11 heart transplant patients (5 of whom had biopsy-proven evidence of rejection) and 19 lung transplant patients (2 of whom had biopsy-proven evidence of rejection). On Kaplan-Meier analysis, the probability of late-onset atrial fibrillation at 5 years was 4.3% for heart transplant patients vs. 13.9% for lung transplant patients (log-rank p = 0.01). Conclusions We documented an increased probability of late-onset atrial fibrillation among bilateral orthotopic lung transplant patients compared to orthotopic heart transplant patients. This was a hypothesis-generating study that suggests a potential role for cardiac autonomic innervation in the genesis of atrial fibrillation.

Original languageEnglish (US)
Pages (from-to)772-778
Number of pages7
JournalAsian Cardiovascular and Thoracic Annals
Volume24
Issue number8
DOIs
StatePublished - Oct 1 2016

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Atrial Fibrillation
Transplants
Lung
Incidence
Body Mass Index
Hypertension
Biopsy
Kaplan-Meier Estimate
Hospitalization
Transplantation

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Magruder, J. Trent ; Plum, William ; Crawford, Todd C. ; Grimm, Joshua C. ; Borja, Marvin C. ; Berger, Ronald D. ; Tandri, Harikrishna ; Calkins, Hugh ; Cameron, Duke E. ; Mandal, Kaushik. / Incidence of late atrial fibrillation in bilateral lung versus heart transplants. In: Asian Cardiovascular and Thoracic Annals. 2016 ; Vol. 24, No. 8. pp. 772-778.
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abstract = "Background We compared the incidence of late-onset atrial fibrillation in orthotopic heart transplant recipients and bilateral orthotopic lung transplant recipients. Methods We reviewed the records of all heart and lung transplant operations carried out in our institution between 1995 and 2015. We performed 1:1 propensity-matching based on patient age, sex, body mass index, and hypertension. Our primary outcome, late-onset atrial fibrillation, was defined as atrial fibrillation occurring after discharge following hospitalization for transplantation. Results Over the study period, 397 orthotopic heart transplants and 240 bilateral orthotopic lung transplants were performed. Propensity matching resulted in 173 pairs who were matched with respect to age, sex, body mass index, and preoperative hypertension. The median follow-up was 5.3 years for heart transplant patients and 3.1 years for lung transplant patients. Late-onset atrial fibrillation occurred in 11 heart transplant patients (5 of whom had biopsy-proven evidence of rejection) and 19 lung transplant patients (2 of whom had biopsy-proven evidence of rejection). On Kaplan-Meier analysis, the probability of late-onset atrial fibrillation at 5 years was 4.3{\%} for heart transplant patients vs. 13.9{\%} for lung transplant patients (log-rank p = 0.01). Conclusions We documented an increased probability of late-onset atrial fibrillation among bilateral orthotopic lung transplant patients compared to orthotopic heart transplant patients. This was a hypothesis-generating study that suggests a potential role for cardiac autonomic innervation in the genesis of atrial fibrillation.",
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Magruder, JT, Plum, W, Crawford, TC, Grimm, JC, Borja, MC, Berger, RD, Tandri, H, Calkins, H, Cameron, DE & Mandal, K 2016, 'Incidence of late atrial fibrillation in bilateral lung versus heart transplants', Asian Cardiovascular and Thoracic Annals, vol. 24, no. 8, pp. 772-778. https://doi.org/10.1177/0218492316669272

Incidence of late atrial fibrillation in bilateral lung versus heart transplants. / Magruder, J. Trent; Plum, William; Crawford, Todd C.; Grimm, Joshua C.; Borja, Marvin C.; Berger, Ronald D.; Tandri, Harikrishna; Calkins, Hugh; Cameron, Duke E.; Mandal, Kaushik.

In: Asian Cardiovascular and Thoracic Annals, Vol. 24, No. 8, 01.10.2016, p. 772-778.

Research output: Contribution to journalArticle

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T1 - Incidence of late atrial fibrillation in bilateral lung versus heart transplants

AU - Magruder, J. Trent

AU - Plum, William

AU - Crawford, Todd C.

AU - Grimm, Joshua C.

AU - Borja, Marvin C.

AU - Berger, Ronald D.

AU - Tandri, Harikrishna

AU - Calkins, Hugh

AU - Cameron, Duke E.

AU - Mandal, Kaushik

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background We compared the incidence of late-onset atrial fibrillation in orthotopic heart transplant recipients and bilateral orthotopic lung transplant recipients. Methods We reviewed the records of all heart and lung transplant operations carried out in our institution between 1995 and 2015. We performed 1:1 propensity-matching based on patient age, sex, body mass index, and hypertension. Our primary outcome, late-onset atrial fibrillation, was defined as atrial fibrillation occurring after discharge following hospitalization for transplantation. Results Over the study period, 397 orthotopic heart transplants and 240 bilateral orthotopic lung transplants were performed. Propensity matching resulted in 173 pairs who were matched with respect to age, sex, body mass index, and preoperative hypertension. The median follow-up was 5.3 years for heart transplant patients and 3.1 years for lung transplant patients. Late-onset atrial fibrillation occurred in 11 heart transplant patients (5 of whom had biopsy-proven evidence of rejection) and 19 lung transplant patients (2 of whom had biopsy-proven evidence of rejection). On Kaplan-Meier analysis, the probability of late-onset atrial fibrillation at 5 years was 4.3% for heart transplant patients vs. 13.9% for lung transplant patients (log-rank p = 0.01). Conclusions We documented an increased probability of late-onset atrial fibrillation among bilateral orthotopic lung transplant patients compared to orthotopic heart transplant patients. This was a hypothesis-generating study that suggests a potential role for cardiac autonomic innervation in the genesis of atrial fibrillation.

AB - Background We compared the incidence of late-onset atrial fibrillation in orthotopic heart transplant recipients and bilateral orthotopic lung transplant recipients. Methods We reviewed the records of all heart and lung transplant operations carried out in our institution between 1995 and 2015. We performed 1:1 propensity-matching based on patient age, sex, body mass index, and hypertension. Our primary outcome, late-onset atrial fibrillation, was defined as atrial fibrillation occurring after discharge following hospitalization for transplantation. Results Over the study period, 397 orthotopic heart transplants and 240 bilateral orthotopic lung transplants were performed. Propensity matching resulted in 173 pairs who were matched with respect to age, sex, body mass index, and preoperative hypertension. The median follow-up was 5.3 years for heart transplant patients and 3.1 years for lung transplant patients. Late-onset atrial fibrillation occurred in 11 heart transplant patients (5 of whom had biopsy-proven evidence of rejection) and 19 lung transplant patients (2 of whom had biopsy-proven evidence of rejection). On Kaplan-Meier analysis, the probability of late-onset atrial fibrillation at 5 years was 4.3% for heart transplant patients vs. 13.9% for lung transplant patients (log-rank p = 0.01). Conclusions We documented an increased probability of late-onset atrial fibrillation among bilateral orthotopic lung transplant patients compared to orthotopic heart transplant patients. This was a hypothesis-generating study that suggests a potential role for cardiac autonomic innervation in the genesis of atrial fibrillation.

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