Incidence, predictors, and outcome of early seizures after mechanical thrombectomy

Mohammad Anadani, Alain Zingraff Lekoubou Looti, Eyad Almallouhi, Ali Alawieh, Arindam Chatterjee, Jan Vargas, Alejandro M. Spiotta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Despite the wide utilization of mechanical thrombectomy (MT) for acute ischemic stroke treatment, little is known about the incidence of early post-thrombectomy seizures, its predictors, and association with long-term outcome. Methods: Using a prospective registry of mechanical thrombectomy in ischemic stroke between January 2013 and July 2017, we identified patients who developed a seizure within 7 days (early seizure) of qualifying event. Backward stepwise regression analysis was used to assess independent predictors of seizure occurrence and the association between seizure and functional outcome (modified Rankin scale of 0–2 vs. ≥3). Results: A total of 459 patients were included in the final analysis. Mean age was 67.5 (SD 15.1), and 49.9% of patients were female. Successful recanalization (TICI≥2B) was achieved in 92.8% of patients. Eleven (2.4%) patients developed at least one seizure. Only an Alberta Stroke Program Early CT (ASPECT) score of <6 was independently associated with the occurrence of early seizures [Odds ratio, 95% confidence interval: 8.188, (2.219–30.214); P =.002]. On multivariate analysis, early seizures were associated with 90-day mortality rate [OR,6.487; 95% confidence interval, (1.481–28.405); P =.013] and poor functional outcome (OR, 4.7; 95% confidence interval (1.08–20.83); p =.039). Conclusion: In the studied cohort, 2.4% of ischemic stroke patients treated with MT developed at least one seizure within 7 days of stroke onset. A low ASPECT score was associated with the occurrence of early seizures. The occurrence of seizures was associated with 90-day mortality and poor functional outcome.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalJournal of the neurological sciences
Volume396
DOIs
StatePublished - Jan 15 2019

Fingerprint

Thrombectomy
Seizures
Incidence
Stroke
Alberta
Confidence Intervals
Mortality
Registries
Multivariate Analysis
Odds Ratio
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Anadani, Mohammad ; Lekoubou Looti, Alain Zingraff ; Almallouhi, Eyad ; Alawieh, Ali ; Chatterjee, Arindam ; Vargas, Jan ; Spiotta, Alejandro M. / Incidence, predictors, and outcome of early seizures after mechanical thrombectomy. In: Journal of the neurological sciences. 2019 ; Vol. 396. pp. 235-239.
@article{db1266e120fa423985b146df437ae614,
title = "Incidence, predictors, and outcome of early seizures after mechanical thrombectomy",
abstract = "Objective: Despite the wide utilization of mechanical thrombectomy (MT) for acute ischemic stroke treatment, little is known about the incidence of early post-thrombectomy seizures, its predictors, and association with long-term outcome. Methods: Using a prospective registry of mechanical thrombectomy in ischemic stroke between January 2013 and July 2017, we identified patients who developed a seizure within 7 days (early seizure) of qualifying event. Backward stepwise regression analysis was used to assess independent predictors of seizure occurrence and the association between seizure and functional outcome (modified Rankin scale of 0–2 vs. ≥3). Results: A total of 459 patients were included in the final analysis. Mean age was 67.5 (SD 15.1), and 49.9{\%} of patients were female. Successful recanalization (TICI≥2B) was achieved in 92.8{\%} of patients. Eleven (2.4{\%}) patients developed at least one seizure. Only an Alberta Stroke Program Early CT (ASPECT) score of <6 was independently associated with the occurrence of early seizures [Odds ratio, 95{\%} confidence interval: 8.188, (2.219–30.214); P =.002]. On multivariate analysis, early seizures were associated with 90-day mortality rate [OR,6.487; 95{\%} confidence interval, (1.481–28.405); P =.013] and poor functional outcome (OR, 4.7; 95{\%} confidence interval (1.08–20.83); p =.039). Conclusion: In the studied cohort, 2.4{\%} of ischemic stroke patients treated with MT developed at least one seizure within 7 days of stroke onset. A low ASPECT score was associated with the occurrence of early seizures. The occurrence of seizures was associated with 90-day mortality and poor functional outcome.",
author = "Mohammad Anadani and {Lekoubou Looti}, {Alain Zingraff} and Eyad Almallouhi and Ali Alawieh and Arindam Chatterjee and Jan Vargas and Spiotta, {Alejandro M.}",
year = "2019",
month = "1",
day = "15",
doi = "10.1016/j.jns.2018.11.033",
language = "English (US)",
volume = "396",
pages = "235--239",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",

}

Incidence, predictors, and outcome of early seizures after mechanical thrombectomy. / Anadani, Mohammad; Lekoubou Looti, Alain Zingraff; Almallouhi, Eyad; Alawieh, Ali; Chatterjee, Arindam; Vargas, Jan; Spiotta, Alejandro M.

In: Journal of the neurological sciences, Vol. 396, 15.01.2019, p. 235-239.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Incidence, predictors, and outcome of early seizures after mechanical thrombectomy

AU - Anadani, Mohammad

AU - Lekoubou Looti, Alain Zingraff

AU - Almallouhi, Eyad

AU - Alawieh, Ali

AU - Chatterjee, Arindam

AU - Vargas, Jan

AU - Spiotta, Alejandro M.

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Objective: Despite the wide utilization of mechanical thrombectomy (MT) for acute ischemic stroke treatment, little is known about the incidence of early post-thrombectomy seizures, its predictors, and association with long-term outcome. Methods: Using a prospective registry of mechanical thrombectomy in ischemic stroke between January 2013 and July 2017, we identified patients who developed a seizure within 7 days (early seizure) of qualifying event. Backward stepwise regression analysis was used to assess independent predictors of seizure occurrence and the association between seizure and functional outcome (modified Rankin scale of 0–2 vs. ≥3). Results: A total of 459 patients were included in the final analysis. Mean age was 67.5 (SD 15.1), and 49.9% of patients were female. Successful recanalization (TICI≥2B) was achieved in 92.8% of patients. Eleven (2.4%) patients developed at least one seizure. Only an Alberta Stroke Program Early CT (ASPECT) score of <6 was independently associated with the occurrence of early seizures [Odds ratio, 95% confidence interval: 8.188, (2.219–30.214); P =.002]. On multivariate analysis, early seizures were associated with 90-day mortality rate [OR,6.487; 95% confidence interval, (1.481–28.405); P =.013] and poor functional outcome (OR, 4.7; 95% confidence interval (1.08–20.83); p =.039). Conclusion: In the studied cohort, 2.4% of ischemic stroke patients treated with MT developed at least one seizure within 7 days of stroke onset. A low ASPECT score was associated with the occurrence of early seizures. The occurrence of seizures was associated with 90-day mortality and poor functional outcome.

AB - Objective: Despite the wide utilization of mechanical thrombectomy (MT) for acute ischemic stroke treatment, little is known about the incidence of early post-thrombectomy seizures, its predictors, and association with long-term outcome. Methods: Using a prospective registry of mechanical thrombectomy in ischemic stroke between January 2013 and July 2017, we identified patients who developed a seizure within 7 days (early seizure) of qualifying event. Backward stepwise regression analysis was used to assess independent predictors of seizure occurrence and the association between seizure and functional outcome (modified Rankin scale of 0–2 vs. ≥3). Results: A total of 459 patients were included in the final analysis. Mean age was 67.5 (SD 15.1), and 49.9% of patients were female. Successful recanalization (TICI≥2B) was achieved in 92.8% of patients. Eleven (2.4%) patients developed at least one seizure. Only an Alberta Stroke Program Early CT (ASPECT) score of <6 was independently associated with the occurrence of early seizures [Odds ratio, 95% confidence interval: 8.188, (2.219–30.214); P =.002]. On multivariate analysis, early seizures were associated with 90-day mortality rate [OR,6.487; 95% confidence interval, (1.481–28.405); P =.013] and poor functional outcome (OR, 4.7; 95% confidence interval (1.08–20.83); p =.039). Conclusion: In the studied cohort, 2.4% of ischemic stroke patients treated with MT developed at least one seizure within 7 days of stroke onset. A low ASPECT score was associated with the occurrence of early seizures. The occurrence of seizures was associated with 90-day mortality and poor functional outcome.

UR - http://www.scopus.com/inward/record.url?scp=85057834799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057834799&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2018.11.033

DO - 10.1016/j.jns.2018.11.033

M3 - Article

C2 - 30529800

AN - SCOPUS:85057834799

VL - 396

SP - 235

EP - 239

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

ER -