Calorimetric studies of the inclusion complexes of straight and branched alcohols and of diols with alpha-cyclodextrin (α-CD) have been carried out in water solvent. The data suggest that straight and branched chain alcohols enter the cavity of α-CD alkyl end first. The hydroxyl group hydrogen bonds to the outer oxygen ring of the cyclodextrin. For branched chain alcohols the longer alkyl part of the molecule penetrates the α-CD cavity up to the hydroxyl group. Diols form two hydrogen bonds to the outer oxygen ring of the cyclodextrin with some penetration into its interior.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Physical and Theoretical Chemistry