Inclusion complexes of alcohols with α-cyclodextrin

J. N. Spencer, Jarusha DeGarmo, Ian Paul, Qing He, Xiaoming Ke, Zhenqing Wu, C. H. Yoder, Shuyun Chen, J. E. Mihalick

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Calorimetric studies of the inclusion complexes of straight and branched alcohols and of diols with alpha-cyclodextrin (α-CD) have been carried out in water solvent. The data suggest that straight and branched chain alcohols enter the cavity of α-CD alkyl end first. The hydroxyl group hydrogen bonds to the outer oxygen ring of the cyclodextrin. For branched chain alcohols the longer alkyl part of the molecule penetrates the α-CD cavity up to the hydroxyl group. Diols form two hydrogen bonds to the outer oxygen ring of the cyclodextrin with some penetration into its interior.

Original languageEnglish (US)
Pages (from-to)601-609
Number of pages9
JournalJournal of Solution Chemistry
Volume24
Issue number6
DOIs
StatePublished - Jun 1995

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Physical and Theoretical Chemistry

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