Increased Amounts of Double-Stranded RNA in the Cytoplasm of Rat Liver Following Treatment with Carcinogens

Gary A. Clawson, Edward A. Smuckler

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cytoplasmic RNA was isolated from control rats or at 48 hr following carcinogen administration. A significant quantity (0.6%) of double-stranded RNA was present in control preparations, as assessed by digestion with RNase Ill. Following carcinogen treatment of rats, this percentage increased significantly. The results suggest that the altered transport of repetitive sequences which is induced by carcinogen treatment involves alterations in the metabolism of double-stranded RNA sequences.

Original languageEnglish (US)
Pages (from-to)3228-3231
Number of pages4
JournalCancer Research
Volume42
Issue number8
StatePublished - Aug 1 1982

Fingerprint

Double-Stranded RNA
Carcinogens
Cytoplasm
Liver
Nucleic Acid Repetitive Sequences
Ribonucleases
Digestion
RNA

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

@article{d662cc1896a54b83bed760ce47ce5be1,
title = "Increased Amounts of Double-Stranded RNA in the Cytoplasm of Rat Liver Following Treatment with Carcinogens",
abstract = "Cytoplasmic RNA was isolated from control rats or at 48 hr following carcinogen administration. A significant quantity (0.6{\%}) of double-stranded RNA was present in control preparations, as assessed by digestion with RNase Ill. Following carcinogen treatment of rats, this percentage increased significantly. The results suggest that the altered transport of repetitive sequences which is induced by carcinogen treatment involves alterations in the metabolism of double-stranded RNA sequences.",
author = "Clawson, {Gary A.} and Smuckler, {Edward A.}",
year = "1982",
month = "8",
day = "1",
language = "English (US)",
volume = "42",
pages = "3228--3231",
journal = "Cancer Research",
issn = "0008-5472",
number = "8",

}

Increased Amounts of Double-Stranded RNA in the Cytoplasm of Rat Liver Following Treatment with Carcinogens. / Clawson, Gary A.; Smuckler, Edward A.

In: Cancer Research, Vol. 42, No. 8, 01.08.1982, p. 3228-3231.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increased Amounts of Double-Stranded RNA in the Cytoplasm of Rat Liver Following Treatment with Carcinogens

AU - Clawson, Gary A.

AU - Smuckler, Edward A.

PY - 1982/8/1

Y1 - 1982/8/1

N2 - Cytoplasmic RNA was isolated from control rats or at 48 hr following carcinogen administration. A significant quantity (0.6%) of double-stranded RNA was present in control preparations, as assessed by digestion with RNase Ill. Following carcinogen treatment of rats, this percentage increased significantly. The results suggest that the altered transport of repetitive sequences which is induced by carcinogen treatment involves alterations in the metabolism of double-stranded RNA sequences.

AB - Cytoplasmic RNA was isolated from control rats or at 48 hr following carcinogen administration. A significant quantity (0.6%) of double-stranded RNA was present in control preparations, as assessed by digestion with RNase Ill. Following carcinogen treatment of rats, this percentage increased significantly. The results suggest that the altered transport of repetitive sequences which is induced by carcinogen treatment involves alterations in the metabolism of double-stranded RNA sequences.

UR - http://www.scopus.com/inward/record.url?scp=0019983750&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019983750&partnerID=8YFLogxK

M3 - Article

C2 - 6807540

AN - SCOPUS:0019983750

VL - 42

SP - 3228

EP - 3231

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 8

ER -