Increased Binding of [3H]GABA to Striatal Membranes Following Ischemia

Andrew Francis, William Pulsinelli

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Abstract

Abstract: Sodium‐independent binding of [3H]γ‐aminobutyric acid ([3H]GABA) to membranes prepared from ischemic‐damaged rat striatum was studied by kinetic and time‐course analysis. Three days after 40 min of ischemia, [3H]GABA binding increased fourfold over control values. Scatchard analysis of the binding showed that ischemia significantly increased the affinity (KD) and the total number of binding sites (Bmax) for the high‐affinity GABA receptor. These results support the conclusion that transient forebrain ischemia damages striatal GABAergic neurons. 1983 International Society for Neurochemistry

Original languageEnglish (US)
Pages (from-to)1497-1499
Number of pages3
JournalJournal of neurochemistry
Volume40
Issue number5
DOIs
StatePublished - Jan 1 1983

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

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