Increased brain size and cellular content in infant rats treated with an opiate antagonist

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

From birth to day 21, rat offspring received daily injections of naltrexone at a dosage that blocked morphine-induced analgesia 24 hours a day. At 21 days, body, brain, and cerebellar weights of naltrexone-injected animals were 18, 11, and 5 percent greater than corresponding control weights. In addition, morphometric analysis of the cerebrum revealed a somatosensory cortex that was 18 percent thicker than that of the controls. The cerebellum of naltrexone-treated rats was 41 percent larger in total area and contained at least 70 percent more glial cells and 30 percent more granule neurons. Neurons derived prenatally were unaffected by drug treatment. These results show that naltrexone can stimulate body and brain growth in rats and suggest a role for the endorphin and opiate receptor system in development.

Original languageEnglish (US)
Pages (from-to)1179-1180
Number of pages2
JournalScience
Volume221
Issue number4616
DOIs
StatePublished - Jan 1 1983

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Opiate Alkaloids
Naltrexone
Brain
Opioid Receptors
Neurons
Weights and Measures
Somatosensory Cortex
Cerebrum
Neuroglia
Analgesia
Cerebellum
Morphine
Parturition
Injections
Growth
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • General

Cite this

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title = "Increased brain size and cellular content in infant rats treated with an opiate antagonist",
abstract = "From birth to day 21, rat offspring received daily injections of naltrexone at a dosage that blocked morphine-induced analgesia 24 hours a day. At 21 days, body, brain, and cerebellar weights of naltrexone-injected animals were 18, 11, and 5 percent greater than corresponding control weights. In addition, morphometric analysis of the cerebrum revealed a somatosensory cortex that was 18 percent thicker than that of the controls. The cerebellum of naltrexone-treated rats was 41 percent larger in total area and contained at least 70 percent more glial cells and 30 percent more granule neurons. Neurons derived prenatally were unaffected by drug treatment. These results show that naltrexone can stimulate body and brain growth in rats and suggest a role for the endorphin and opiate receptor system in development.",
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Increased brain size and cellular content in infant rats treated with an opiate antagonist. / Zagon, Ian S.; Mclaughlin, Patricia J.

In: Science, Vol. 221, No. 4616, 01.01.1983, p. 1179-1180.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increased brain size and cellular content in infant rats treated with an opiate antagonist

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