Increased early enteral zinc intake improves weight gain in hospitalised preterm infants

Tracey Harris, Fumiyuki Gardner, Abigail Podany, Shannon L. Kelleher, Kim K. Doheny

Research output: Contribution to journalArticle

Abstract

Aim: To test the hypothesis that enteral zinc intake is associated with improved preterm infant growth during neonatal intensive care unit (NICU) hospitalisation. Methods: This prospective cohort study enrolled 105 preterm infants at a tertiary referral centre. Enteral zinc intake was calculated at day of life 14, and growth was measured as change in weight, length and head circumference from birth to discharge. Nonparametric tests assessed the contribution of breast milk vs formula and enteral zinc intake on weight, length and head circumference growth. Partial correlations evaluated the impact of baseline health status and caloric intake on growth. Multiple regression analysis was then completed to determine the unique contribution of zinc intake to weight gain and head circumference growth. Results: Total enteral zinc intake was positively associated with weight gain (r = 0.4, p < 0.01) and head circumference growth (r = 0.3, p < 0.01) during NICU hospitalisation. Further, multiple regression analysis showed higher zinc intake is linked to weight gain during NICU hospitalisation after accounting for postmenstrual age at birth. Conclusion: Increased early enteral zinc intake is linked to weight gain during NICU hospitalisation, highlighting the importance of enteral zinc intake in early infant nutrition.

Original languageEnglish (US)
Pages (from-to)1978-1984
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics
Volume108
Issue number11
DOIs
StatePublished - Nov 1 2019

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Premature Infants
Small Intestine
Weight Gain
Zinc
Neonatal Intensive Care Units
Hospitalization
Growth
Head
Regression Analysis
Parturition
Weights and Measures
Human Milk
Energy Intake
Tertiary Care Centers
Health Status
Cohort Studies
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Harris, Tracey ; Gardner, Fumiyuki ; Podany, Abigail ; Kelleher, Shannon L. ; Doheny, Kim K. / Increased early enteral zinc intake improves weight gain in hospitalised preterm infants. In: Acta Paediatrica, International Journal of Paediatrics. 2019 ; Vol. 108, No. 11. pp. 1978-1984.
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Increased early enteral zinc intake improves weight gain in hospitalised preterm infants. / Harris, Tracey; Gardner, Fumiyuki; Podany, Abigail; Kelleher, Shannon L.; Doheny, Kim K.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 108, No. 11, 01.11.2019, p. 1978-1984.

Research output: Contribution to journalArticle

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