Increased forskolin stimulation of lymphocyte-adenylate cyclase in normotensive subjects predisposed to essential hypertension

Klaus Detlev Schultz, Emanuel Fritschka, Linda B. Pauliks, Thomas Philipp, Arnim Distler

Research output: Contribution to journalArticle

Abstract

Since a significant heritabiiity has been shown for forskolin stimulation of lymphocyte adenylate cyclase activity in twins, we evaluated lymphocyte forskolin-stimulated adenylate cyc-lase activity with respect to a familial predisposition towards essential hypertension. Lymphocyte adenylate cyclase activity was measured in broken cell preparations of 32 male normotensive volunteers with (n = 15) and without (n = 17) a positive family history of hypertension. The maximal forskolin stimulation of adenylate cyclase activity was significantly higher in the positive com-pared with the negative group (maximal stimulation of ac- itvity 53.5 ± 3.4 versus 41.2 ± 1.9pmol cyclic AMP (cAMP)/mg protein per min; P< 0.01). Dose-response curves showed a significantly greater stimulation of adenylate cyclase activity in the positive group at forskolin concentrations of 10-7to 2 x 10-4mol/l. The median effective dose (ED50) and adenylate cyclase activity in the absence of forskolin were similar in both groups. We conclude that lymphocyte forskolin-stimulated adenylate cyclase activity may depend in part on hereditary factors associated with a familial predisposition to essential hypertension.

Original languageEnglish (US)
Pages (from-to)S142-S143
JournalJournal of Hypertension, Supplement
Volume7
StatePublished - Jan 1 1989

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Colforsin
Lymphocyte Activation
Adenylyl Cyclases
Lymphocytes
Cyclic AMP
Essential Hypertension
Volunteers
Hypertension
Proteins

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Schultz, Klaus Detlev ; Fritschka, Emanuel ; Pauliks, Linda B. ; Philipp, Thomas ; Distler, Arnim. / Increased forskolin stimulation of lymphocyte-adenylate cyclase in normotensive subjects predisposed to essential hypertension. In: Journal of Hypertension, Supplement. 1989 ; Vol. 7. pp. S142-S143.
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Increased forskolin stimulation of lymphocyte-adenylate cyclase in normotensive subjects predisposed to essential hypertension. / Schultz, Klaus Detlev; Fritschka, Emanuel; Pauliks, Linda B.; Philipp, Thomas; Distler, Arnim.

In: Journal of Hypertension, Supplement, Vol. 7, 01.01.1989, p. S142-S143.

Research output: Contribution to journalArticle

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