Increased frequency of alleles associated with elevated tumor necrosis factor-α levels in children with Kawasaki disease

M. W. Quasney, D. E. Bronstein, R. M. Cantor, Q. Zhang, C. Stroupe, H. Shike, J. F. Bastian, T. Matsubara, M. Fujiwara, K. Akimoto, J. W. Newburger, J. C. Burns

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Genetic polymorphisms influence the magnitude of the cytokine response after an inflammatory stimulus. To determine whether such polymorphisms might play a role in Kawasaki disease (KD), we analyzed white and Japanese children with KD and control populations for two polymorphic loci in which the A allele is associated with high tumor necrosis factor-α secretion. The lymphotoxin-α+250 A/A genotype was overrepresented among white children with KD compared with controls (0.59 versus 0.36; p = 0.013). The tumor necrosis factor-α-308 A/G genotype was overrepresented among whites with KD who had coronary artery abnormalities compared with those with normal echocardiograms (0.36 versus 0.09; p = 0.044). No significant difference was seen at either locus between Japanese children with KD and Japanese controls. The increased frequency of the high secretor alleles in white children with KD suggests that these loci may be related to susceptibility to KD and to outcome after disease.

Original languageEnglish (US)
Pages (from-to)686-690
Number of pages5
JournalPediatric Research
Volume49
Issue number5
DOIs
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Increased frequency of alleles associated with elevated tumor necrosis factor-α levels in children with Kawasaki disease'. Together they form a unique fingerprint.

  • Cite this

    Quasney, M. W., Bronstein, D. E., Cantor, R. M., Zhang, Q., Stroupe, C., Shike, H., Bastian, J. F., Matsubara, T., Fujiwara, M., Akimoto, K., Newburger, J. W., & Burns, J. C. (2001). Increased frequency of alleles associated with elevated tumor necrosis factor-α levels in children with Kawasaki disease. Pediatric Research, 49(5), 686-690. https://doi.org/10.1203/00006450-200105000-00013