Increased intestinal clearance of α1-antitrypsin in patients with α1-antitrypsin deficiency

Bruce B. Grill, Thomas Tinghitella, Craig Hillemeier, Joyce Gryboski

Research output: Contribution to journalArticle

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Abstract

To evaluate the possible contribution of enteric losses ofα1-antitrypsin (α1-AT) to the low serum levels of a,-AT seen in patients with a,-AT deficiency, we investigated intestinal clearance of α1-AT (C-α1,-AT) in five of these patients (mean age 3.4 years) and compared it to that of 10 patients (mean age 3.7 years) with gastrointestinal disorders and normal serum albumin values who served as controls. C-α1-AT was also determined in four patients (mean age 9 months) with noncirrhotic liver disease. The percent of daily α1-AT turnover which could be attributed to stool losses was calculated in these groups of patients, α1-AT was measured in stool and serum by radial immunodiffusion and the clearance calculated. The mean C-α1-AT in the patients with α1-AT deficiency was significantly (p < 0.05) higher than that of the controls. The liver disease patients had values for C-α1-AT in the range of the controls. Three of the α1-AT deficiency patients had values for C-α1-AT greater than the mean plus 3 SD of the control, but these were not in the range seen in patients with protein losing enteropathy. Mean percent contribution of stool losses to total daily α1-AT turnover was similar in all three groups. We conclude that patients with α1-AT deficiency have increased fecal clearance of α1-AT seemingly unrelated to the liver disease, but that this is not a major cause of the low serum levels.

Original languageEnglish (US)
Pages (from-to)95-98
Number of pages4
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume2
Issue number1
DOIs
StatePublished - Jan 1 1983

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Liver Diseases
Serum
Protein-Losing Enteropathies
Immunodiffusion
Serum Albumin

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

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title = "Increased intestinal clearance of α1-antitrypsin in patients with α1-antitrypsin deficiency",
abstract = "To evaluate the possible contribution of enteric losses ofα1-antitrypsin (α1-AT) to the low serum levels of a,-AT seen in patients with a,-AT deficiency, we investigated intestinal clearance of α1-AT (C-α1,-AT) in five of these patients (mean age 3.4 years) and compared it to that of 10 patients (mean age 3.7 years) with gastrointestinal disorders and normal serum albumin values who served as controls. C-α1-AT was also determined in four patients (mean age 9 months) with noncirrhotic liver disease. The percent of daily α1-AT turnover which could be attributed to stool losses was calculated in these groups of patients, α1-AT was measured in stool and serum by radial immunodiffusion and the clearance calculated. The mean C-α1-AT in the patients with α1-AT deficiency was significantly (p < 0.05) higher than that of the controls. The liver disease patients had values for C-α1-AT in the range of the controls. Three of the α1-AT deficiency patients had values for C-α1-AT greater than the mean plus 3 SD of the control, but these were not in the range seen in patients with protein losing enteropathy. Mean percent contribution of stool losses to total daily α1-AT turnover was similar in all three groups. We conclude that patients with α1-AT deficiency have increased fecal clearance of α1-AT seemingly unrelated to the liver disease, but that this is not a major cause of the low serum levels.",
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Increased intestinal clearance of α1-antitrypsin in patients with α1-antitrypsin deficiency. / Grill, Bruce B.; Tinghitella, Thomas; Hillemeier, Craig; Gryboski, Joyce.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 2, No. 1, 01.01.1983, p. 95-98.

Research output: Contribution to journalArticle

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