Abstract

Welding has been associated with neurobehavioral disorders.Welding fumes contain severalmetals including copper (Cu), manganese (Mn), and iron (Fe) thatmay interact to influence welding-related neurotoxicity. Although welding-related airborne Fe levels are about 10-fold higher than Mn, previous studies have focused on Mn and its accumulation in the basal ganglia. This study examined differences in the apparent transverse relaxation rates [R2* (1/T2*), estimate of Fe accumulation] in the basal ganglia (caudate nucleus, putamen, and globus pallidus) between welders and controls, and the dose-response relationship between estimated Fe exposure and R2* values. Occupational questionnaires estimated recent and lifetime Fe exposure, and blood Fe levels and brainmagnetic resonance imaging (MRI) were obtained. Complete exposure and MRI R2* and R1 (1/T1:measure to estimate Mn accumulation) data from42 subjects with welding exposure and 29 controls were analyzed.Welders had significantly greater exposuremetrics and higher whole-blood Fe levels compared with controls. R2* in the caudate nucleus was significantly higher in welders after controlling for age, bodymass index, respirator use, caudate R1, and bloodmetals of Cu and Mn, whereas there was no difference in R1 values in the basal ganglia between groups. The R2* in the caudate nucleus was positively correlated with whole-blood Fe concentration. This study provides the first evidence of higher R2* in the caudate nucleus of welders, which is suggestive of increased Fe accumulation in this area. Further studies are needed to replicate the findings and determine the neurobehavioral relevance.

Original languageEnglish (US)
Article numberkfv331
Pages (from-to)369-377
Number of pages9
JournalToxicological Sciences
Volume150
Issue number2
DOIs
StatePublished - Apr 1 2016

Fingerprint

Welding
Caudate Nucleus
Manganese
Basal Ganglia
Blood
Magnetic resonance imaging
Respirators
Fumes
Globus Pallidus
Putamen
Mechanical Ventilators
Copper
Iron
Imaging techniques

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Lee, Eun Young ; Flynn, Michael R. ; Du, Guangwei ; Li, Yunqing ; Lewis, Mechelle M. ; Herring, Amy H. ; Buren, Eric Van ; Buren, Scott Van ; Kong, Lan ; Fry, Rebecca C. ; Snyder, Amanda M. ; Connor, James R. ; Yang, Qing X. ; Mailman, Richard B. ; Huang, Xuemei. / Increased R2* in the caudate nucleus of asymptomatic welders. In: Toxicological Sciences. 2016 ; Vol. 150, No. 2. pp. 369-377.
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abstract = "Welding has been associated with neurobehavioral disorders.Welding fumes contain severalmetals including copper (Cu), manganese (Mn), and iron (Fe) thatmay interact to influence welding-related neurotoxicity. Although welding-related airborne Fe levels are about 10-fold higher than Mn, previous studies have focused on Mn and its accumulation in the basal ganglia. This study examined differences in the apparent transverse relaxation rates [R2* (1/T2*), estimate of Fe accumulation] in the basal ganglia (caudate nucleus, putamen, and globus pallidus) between welders and controls, and the dose-response relationship between estimated Fe exposure and R2* values. Occupational questionnaires estimated recent and lifetime Fe exposure, and blood Fe levels and brainmagnetic resonance imaging (MRI) were obtained. Complete exposure and MRI R2* and R1 (1/T1:measure to estimate Mn accumulation) data from42 subjects with welding exposure and 29 controls were analyzed.Welders had significantly greater exposuremetrics and higher whole-blood Fe levels compared with controls. R2* in the caudate nucleus was significantly higher in welders after controlling for age, bodymass index, respirator use, caudate R1, and bloodmetals of Cu and Mn, whereas there was no difference in R1 values in the basal ganglia between groups. The R2* in the caudate nucleus was positively correlated with whole-blood Fe concentration. This study provides the first evidence of higher R2* in the caudate nucleus of welders, which is suggestive of increased Fe accumulation in this area. Further studies are needed to replicate the findings and determine the neurobehavioral relevance.",
author = "Lee, {Eun Young} and Flynn, {Michael R.} and Guangwei Du and Yunqing Li and Lewis, {Mechelle M.} and Herring, {Amy H.} and Buren, {Eric Van} and Buren, {Scott Van} and Lan Kong and Fry, {Rebecca C.} and Snyder, {Amanda M.} and Connor, {James R.} and Yang, {Qing X.} and Mailman, {Richard B.} and Xuemei Huang",
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Increased R2* in the caudate nucleus of asymptomatic welders. / Lee, Eun Young; Flynn, Michael R.; Du, Guangwei; Li, Yunqing; Lewis, Mechelle M.; Herring, Amy H.; Buren, Eric Van; Buren, Scott Van; Kong, Lan; Fry, Rebecca C.; Snyder, Amanda M.; Connor, James R.; Yang, Qing X.; Mailman, Richard B.; Huang, Xuemei.

In: Toxicological Sciences, Vol. 150, No. 2, kfv331, 01.04.2016, p. 369-377.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Increased R2* in the caudate nucleus of asymptomatic welders

AU - Lee, Eun Young

AU - Flynn, Michael R.

AU - Du, Guangwei

AU - Li, Yunqing

AU - Lewis, Mechelle M.

AU - Herring, Amy H.

AU - Buren, Eric Van

AU - Buren, Scott Van

AU - Kong, Lan

AU - Fry, Rebecca C.

AU - Snyder, Amanda M.

AU - Connor, James R.

AU - Yang, Qing X.

AU - Mailman, Richard B.

AU - Huang, Xuemei

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Welding has been associated with neurobehavioral disorders.Welding fumes contain severalmetals including copper (Cu), manganese (Mn), and iron (Fe) thatmay interact to influence welding-related neurotoxicity. Although welding-related airborne Fe levels are about 10-fold higher than Mn, previous studies have focused on Mn and its accumulation in the basal ganglia. This study examined differences in the apparent transverse relaxation rates [R2* (1/T2*), estimate of Fe accumulation] in the basal ganglia (caudate nucleus, putamen, and globus pallidus) between welders and controls, and the dose-response relationship between estimated Fe exposure and R2* values. Occupational questionnaires estimated recent and lifetime Fe exposure, and blood Fe levels and brainmagnetic resonance imaging (MRI) were obtained. Complete exposure and MRI R2* and R1 (1/T1:measure to estimate Mn accumulation) data from42 subjects with welding exposure and 29 controls were analyzed.Welders had significantly greater exposuremetrics and higher whole-blood Fe levels compared with controls. R2* in the caudate nucleus was significantly higher in welders after controlling for age, bodymass index, respirator use, caudate R1, and bloodmetals of Cu and Mn, whereas there was no difference in R1 values in the basal ganglia between groups. The R2* in the caudate nucleus was positively correlated with whole-blood Fe concentration. This study provides the first evidence of higher R2* in the caudate nucleus of welders, which is suggestive of increased Fe accumulation in this area. Further studies are needed to replicate the findings and determine the neurobehavioral relevance.

AB - Welding has been associated with neurobehavioral disorders.Welding fumes contain severalmetals including copper (Cu), manganese (Mn), and iron (Fe) thatmay interact to influence welding-related neurotoxicity. Although welding-related airborne Fe levels are about 10-fold higher than Mn, previous studies have focused on Mn and its accumulation in the basal ganglia. This study examined differences in the apparent transverse relaxation rates [R2* (1/T2*), estimate of Fe accumulation] in the basal ganglia (caudate nucleus, putamen, and globus pallidus) between welders and controls, and the dose-response relationship between estimated Fe exposure and R2* values. Occupational questionnaires estimated recent and lifetime Fe exposure, and blood Fe levels and brainmagnetic resonance imaging (MRI) were obtained. Complete exposure and MRI R2* and R1 (1/T1:measure to estimate Mn accumulation) data from42 subjects with welding exposure and 29 controls were analyzed.Welders had significantly greater exposuremetrics and higher whole-blood Fe levels compared with controls. R2* in the caudate nucleus was significantly higher in welders after controlling for age, bodymass index, respirator use, caudate R1, and bloodmetals of Cu and Mn, whereas there was no difference in R1 values in the basal ganglia between groups. The R2* in the caudate nucleus was positively correlated with whole-blood Fe concentration. This study provides the first evidence of higher R2* in the caudate nucleus of welders, which is suggestive of increased Fe accumulation in this area. Further studies are needed to replicate the findings and determine the neurobehavioral relevance.

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