Increased urinary excretion of pyridinium cross-links in cancer patients

A. Lipton, L. Demers, Y. Daniloff, E. Curley, C. Hamilton, H. Harvey, L. Witters, J. Seaman, R. Van der Giessen, S. Seyedin

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Pyridinoline (PYD) and deoxypyridinoline (DPD), two collagen-based cross- links found in bone, were measured by high-performance liquid chromatography in urine samples from 65 control subjects and 97 patients with either untreated or progressive cancer. Patients with cancer had significantly (P <0.001) higher urine concentrations of PYD and DPD than did control subjects. Both cross-links were increased in cancer patients with and without clinically detectable bone metastases, although patients with bone and liver involvement had higher mean concentrations. The mean concentrations of both cross-links were also significantly higher in the urine samples of inpatients than in an outpatient ambulatory population. These findings suggest that the measurement of PYD and DPD in urine may be useful in assessing bone metastases and bone resorption in cancer patients.

Original languageEnglish (US)
Pages (from-to)614-618
Number of pages5
JournalClinical Chemistry
Volume39
Issue number4
StatePublished - Jan 1 1993

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Bone
Urine
Bone and Bones
Neoplasms
Neoplasm Metastasis
High performance liquid chromatography
Bone Resorption
Liver
Inpatients
Outpatients
Collagen
High Pressure Liquid Chromatography
Population
pyridinoline
deoxypyridinoline

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Lipton, A., Demers, L., Daniloff, Y., Curley, E., Hamilton, C., Harvey, H., ... Seyedin, S. (1993). Increased urinary excretion of pyridinium cross-links in cancer patients. Clinical Chemistry, 39(4), 614-618.
Lipton, A. ; Demers, L. ; Daniloff, Y. ; Curley, E. ; Hamilton, C. ; Harvey, H. ; Witters, L. ; Seaman, J. ; Van der Giessen, R. ; Seyedin, S. / Increased urinary excretion of pyridinium cross-links in cancer patients. In: Clinical Chemistry. 1993 ; Vol. 39, No. 4. pp. 614-618.
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Lipton, A, Demers, L, Daniloff, Y, Curley, E, Hamilton, C, Harvey, H, Witters, L, Seaman, J, Van der Giessen, R & Seyedin, S 1993, 'Increased urinary excretion of pyridinium cross-links in cancer patients', Clinical Chemistry, vol. 39, no. 4, pp. 614-618.

Increased urinary excretion of pyridinium cross-links in cancer patients. / Lipton, A.; Demers, L.; Daniloff, Y.; Curley, E.; Hamilton, C.; Harvey, H.; Witters, L.; Seaman, J.; Van der Giessen, R.; Seyedin, S.

In: Clinical Chemistry, Vol. 39, No. 4, 01.01.1993, p. 614-618.

Research output: Contribution to journalArticle

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T1 - Increased urinary excretion of pyridinium cross-links in cancer patients

AU - Lipton, A.

AU - Demers, L.

AU - Daniloff, Y.

AU - Curley, E.

AU - Hamilton, C.

AU - Harvey, H.

AU - Witters, L.

AU - Seaman, J.

AU - Van der Giessen, R.

AU - Seyedin, S.

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N2 - Pyridinoline (PYD) and deoxypyridinoline (DPD), two collagen-based cross- links found in bone, were measured by high-performance liquid chromatography in urine samples from 65 control subjects and 97 patients with either untreated or progressive cancer. Patients with cancer had significantly (P <0.001) higher urine concentrations of PYD and DPD than did control subjects. Both cross-links were increased in cancer patients with and without clinically detectable bone metastases, although patients with bone and liver involvement had higher mean concentrations. The mean concentrations of both cross-links were also significantly higher in the urine samples of inpatients than in an outpatient ambulatory population. These findings suggest that the measurement of PYD and DPD in urine may be useful in assessing bone metastases and bone resorption in cancer patients.

AB - Pyridinoline (PYD) and deoxypyridinoline (DPD), two collagen-based cross- links found in bone, were measured by high-performance liquid chromatography in urine samples from 65 control subjects and 97 patients with either untreated or progressive cancer. Patients with cancer had significantly (P <0.001) higher urine concentrations of PYD and DPD than did control subjects. Both cross-links were increased in cancer patients with and without clinically detectable bone metastases, although patients with bone and liver involvement had higher mean concentrations. The mean concentrations of both cross-links were also significantly higher in the urine samples of inpatients than in an outpatient ambulatory population. These findings suggest that the measurement of PYD and DPD in urine may be useful in assessing bone metastases and bone resorption in cancer patients.

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Lipton A, Demers L, Daniloff Y, Curley E, Hamilton C, Harvey H et al. Increased urinary excretion of pyridinium cross-links in cancer patients. Clinical Chemistry. 1993 Jan 1;39(4):614-618.