Independent deficits of visual word and motion processing in aging and early Alzheimer's disease

Carla Velarde, Elizabeth Perelstein, Wendy Ressmann, Charles J. Duffy

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

We tested whether visual processing impairments in aging and Alzheimer's disease (AD) reflect uniform posterior cortical decline, or independent disorders of visual processing for reading and navigation. Young and older normal controls were compared to early AD patients using psychophysical measures of visual word and motion processing. We find elevated perceptual thresholds for letters and word discrimination from young normal controls, to older normal controls, to early AD patients. Across subject groups, visual motion processing showed a similar pattern of increasing thresholds, with the greatest impact on radial pattern motion perception. Combined analyses show that letter, word, and motion processing impairments are independent of each other. Aging and AD may be accompanied by independent impairments of visual processing for reading and navigation. This suggests separate underlying disorders and highlights the need for comprehensive evaluations to detect early deficits.

Original languageEnglish (US)
Pages (from-to)613-621
Number of pages9
JournalJournal of Alzheimer's Disease
Volume31
Issue number3
DOIs
StatePublished - 2012

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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