Abstract
We tested whether visual processing impairments in aging and Alzheimer's disease (AD) reflect uniform posterior cortical decline, or independent disorders of visual processing for reading and navigation. Young and older normal controls were compared to early AD patients using psychophysical measures of visual word and motion processing. We find elevated perceptual thresholds for letters and word discrimination from young normal controls, to older normal controls, to early AD patients. Across subject groups, visual motion processing showed a similar pattern of increasing thresholds, with the greatest impact on radial pattern motion perception. Combined analyses show that letter, word, and motion processing impairments are independent of each other. Aging and AD may be accompanied by independent impairments of visual processing for reading and navigation. This suggests separate underlying disorders and highlights the need for comprehensive evaluations to detect early deficits.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 613-621 |
| Number of pages | 9 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 2012 |
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All Science Journal Classification (ASJC) codes
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health
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Independent deficits of visual word and motion processing in aging and early Alzheimer's disease. / Velarde, Carla; Perelstein, Elizabeth; Ressmann, Wendy; Duffy, Charles.
In: Journal of Alzheimer's Disease, Vol. 31, No. 3, 01.01.2012, p. 613-621.Research output: Contribution to journal › Article
TY - JOUR
T1 - Independent deficits of visual word and motion processing in aging and early Alzheimer's disease
AU - Velarde, Carla
AU - Perelstein, Elizabeth
AU - Ressmann, Wendy
AU - Duffy, Charles
PY - 2012/1/1
Y1 - 2012/1/1
N2 - We tested whether visual processing impairments in aging and Alzheimer's disease (AD) reflect uniform posterior cortical decline, or independent disorders of visual processing for reading and navigation. Young and older normal controls were compared to early AD patients using psychophysical measures of visual word and motion processing. We find elevated perceptual thresholds for letters and word discrimination from young normal controls, to older normal controls, to early AD patients. Across subject groups, visual motion processing showed a similar pattern of increasing thresholds, with the greatest impact on radial pattern motion perception. Combined analyses show that letter, word, and motion processing impairments are independent of each other. Aging and AD may be accompanied by independent impairments of visual processing for reading and navigation. This suggests separate underlying disorders and highlights the need for comprehensive evaluations to detect early deficits.
AB - We tested whether visual processing impairments in aging and Alzheimer's disease (AD) reflect uniform posterior cortical decline, or independent disorders of visual processing for reading and navigation. Young and older normal controls were compared to early AD patients using psychophysical measures of visual word and motion processing. We find elevated perceptual thresholds for letters and word discrimination from young normal controls, to older normal controls, to early AD patients. Across subject groups, visual motion processing showed a similar pattern of increasing thresholds, with the greatest impact on radial pattern motion perception. Combined analyses show that letter, word, and motion processing impairments are independent of each other. Aging and AD may be accompanied by independent impairments of visual processing for reading and navigation. This suggests separate underlying disorders and highlights the need for comprehensive evaluations to detect early deficits.
UR - http://www.scopus.com/inward/record.url?scp=84865603082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865603082&partnerID=8YFLogxK
U2 - 10.3233/JAD-2012-112201
DO - 10.3233/JAD-2012-112201
M3 - Article
VL - 31
SP - 613
EP - 621
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 3
ER -