Individual, area, and provider characteristics associated with care received for stages I to III breast cancer in a multistate region of Appalachia

Gretchen G. Kimmick, Fabian Camacho, Heath B. Mackley, Teresa Kern, Nengliang Yao, Stephen A. Matthews, Steven Fleming, Joseph Lipscomb, Jason Liao, Wenke Hwang, Roger T. Anderson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: We describe individual, area, and provider characteristics associated with care patterns for early-stage breast cancer in Appalachian counties of Kentucky, North Carolina, Ohio, and Pennsylvania. Methods: Cases of stages I to III breast cancer from 2006 to 2008 were linked to Medicare claims occurring within 1 year of diagnosis. Rates of guideline-concordant endocrine therapy (n = 1,429), chemotherapy (n = 1,480), and radiation therapy (RT) after breast-conserving surgery were studied; RT was studied in women age ≥ 70 years with stage I estrogen receptor (ER)-positive/progesterone receptor (PR)-positive cancer, for whom RT was optional (n = 1,108), and in all others, for whom RT was guideline concordant (n = 1,422). Univariable and multivariable analyses were performed. Independent variables included age, race, county-level economic status, state, surgeon graduation year and volume, comorbidity, diagnosis year, Medicaid/Medicare dual status, histology, tumor size, tumor sequence, positive lymph nodes, ER/PR status, stage, trastuzumab use, and surgery type. Results: Population mean age was 74 years; 97% were white. For endocrine therapy, chemotherapy, and RT, guideline concordance was 76%, 48%, and 83%, respectively. Where it was optional, 77% received RT. Guideline-concordant endocrine therapy was lower in North Carolina versus Pennsylvania (odds ratio [OR], 0.60; 95% CI, 0.41 to 0.88) and higher if surgeon graduated between 1984 and 1988 versus ≥ 1989 (OR, 1.58; 95% CI, 1.06 to 2.34). Guideline-concordant chemotherapy varied significantly by state, county-level economic status, and surgeon volume. In guideline-concordant RT, lower surgeon volume (v highest) predicted RT use (OR, 1.63; 95% CI, 1.61 to 2.36). In optional RT, North Carolina residence (v Pennsylvania; OR, 0.29; 95% CI, 0.17 to 0.48) and counties with higher economic status (OR, 0.61; 95% CI, 0.40 to 0.94) predicated RT omission. Conclusion: Notable variation in care by geographic and surgical provider characteristics provides targets for further research in underserved areas.

Original languageEnglish (US)
Pages (from-to)e9-e18
JournalJournal of oncology practice
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2015

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Appalachian Region
Radiotherapy
Breast Neoplasms
Guidelines
Odds Ratio
Economics
Progesterone Receptors
Medicare
Drug Therapy
Estrogen Receptors
Neoplasms
Segmental Mastectomy
Medicaid
Comorbidity
Histology
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Oncology(nursing)
  • Health Policy

Cite this

@article{9c75f3849b8a41988274a1eb4e745bd8,
title = "Individual, area, and provider characteristics associated with care received for stages I to III breast cancer in a multistate region of Appalachia",
abstract = "Purpose: We describe individual, area, and provider characteristics associated with care patterns for early-stage breast cancer in Appalachian counties of Kentucky, North Carolina, Ohio, and Pennsylvania. Methods: Cases of stages I to III breast cancer from 2006 to 2008 were linked to Medicare claims occurring within 1 year of diagnosis. Rates of guideline-concordant endocrine therapy (n = 1,429), chemotherapy (n = 1,480), and radiation therapy (RT) after breast-conserving surgery were studied; RT was studied in women age ≥ 70 years with stage I estrogen receptor (ER)-positive/progesterone receptor (PR)-positive cancer, for whom RT was optional (n = 1,108), and in all others, for whom RT was guideline concordant (n = 1,422). Univariable and multivariable analyses were performed. Independent variables included age, race, county-level economic status, state, surgeon graduation year and volume, comorbidity, diagnosis year, Medicaid/Medicare dual status, histology, tumor size, tumor sequence, positive lymph nodes, ER/PR status, stage, trastuzumab use, and surgery type. Results: Population mean age was 74 years; 97{\%} were white. For endocrine therapy, chemotherapy, and RT, guideline concordance was 76{\%}, 48{\%}, and 83{\%}, respectively. Where it was optional, 77{\%} received RT. Guideline-concordant endocrine therapy was lower in North Carolina versus Pennsylvania (odds ratio [OR], 0.60; 95{\%} CI, 0.41 to 0.88) and higher if surgeon graduated between 1984 and 1988 versus ≥ 1989 (OR, 1.58; 95{\%} CI, 1.06 to 2.34). Guideline-concordant chemotherapy varied significantly by state, county-level economic status, and surgeon volume. In guideline-concordant RT, lower surgeon volume (v highest) predicted RT use (OR, 1.63; 95{\%} CI, 1.61 to 2.36). In optional RT, North Carolina residence (v Pennsylvania; OR, 0.29; 95{\%} CI, 0.17 to 0.48) and counties with higher economic status (OR, 0.61; 95{\%} CI, 0.40 to 0.94) predicated RT omission. Conclusion: Notable variation in care by geographic and surgical provider characteristics provides targets for further research in underserved areas.",
author = "Kimmick, {Gretchen G.} and Fabian Camacho and Mackley, {Heath B.} and Teresa Kern and Nengliang Yao and Matthews, {Stephen A.} and Steven Fleming and Joseph Lipscomb and Jason Liao and Wenke Hwang and Anderson, {Roger T.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1200/JOP.2014.001397",
language = "English (US)",
volume = "11",
pages = "e9--e18",
journal = "Journal of Oncology Practice",
issn = "1554-7477",
publisher = "American Society of Clinical Oncology",
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}

Individual, area, and provider characteristics associated with care received for stages I to III breast cancer in a multistate region of Appalachia. / Kimmick, Gretchen G.; Camacho, Fabian; Mackley, Heath B.; Kern, Teresa; Yao, Nengliang; Matthews, Stephen A.; Fleming, Steven; Lipscomb, Joseph; Liao, Jason; Hwang, Wenke; Anderson, Roger T.

In: Journal of oncology practice, Vol. 11, No. 1, 01.01.2015, p. e9-e18.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Individual, area, and provider characteristics associated with care received for stages I to III breast cancer in a multistate region of Appalachia

AU - Kimmick, Gretchen G.

AU - Camacho, Fabian

AU - Mackley, Heath B.

AU - Kern, Teresa

AU - Yao, Nengliang

AU - Matthews, Stephen A.

AU - Fleming, Steven

AU - Lipscomb, Joseph

AU - Liao, Jason

AU - Hwang, Wenke

AU - Anderson, Roger T.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Purpose: We describe individual, area, and provider characteristics associated with care patterns for early-stage breast cancer in Appalachian counties of Kentucky, North Carolina, Ohio, and Pennsylvania. Methods: Cases of stages I to III breast cancer from 2006 to 2008 were linked to Medicare claims occurring within 1 year of diagnosis. Rates of guideline-concordant endocrine therapy (n = 1,429), chemotherapy (n = 1,480), and radiation therapy (RT) after breast-conserving surgery were studied; RT was studied in women age ≥ 70 years with stage I estrogen receptor (ER)-positive/progesterone receptor (PR)-positive cancer, for whom RT was optional (n = 1,108), and in all others, for whom RT was guideline concordant (n = 1,422). Univariable and multivariable analyses were performed. Independent variables included age, race, county-level economic status, state, surgeon graduation year and volume, comorbidity, diagnosis year, Medicaid/Medicare dual status, histology, tumor size, tumor sequence, positive lymph nodes, ER/PR status, stage, trastuzumab use, and surgery type. Results: Population mean age was 74 years; 97% were white. For endocrine therapy, chemotherapy, and RT, guideline concordance was 76%, 48%, and 83%, respectively. Where it was optional, 77% received RT. Guideline-concordant endocrine therapy was lower in North Carolina versus Pennsylvania (odds ratio [OR], 0.60; 95% CI, 0.41 to 0.88) and higher if surgeon graduated between 1984 and 1988 versus ≥ 1989 (OR, 1.58; 95% CI, 1.06 to 2.34). Guideline-concordant chemotherapy varied significantly by state, county-level economic status, and surgeon volume. In guideline-concordant RT, lower surgeon volume (v highest) predicted RT use (OR, 1.63; 95% CI, 1.61 to 2.36). In optional RT, North Carolina residence (v Pennsylvania; OR, 0.29; 95% CI, 0.17 to 0.48) and counties with higher economic status (OR, 0.61; 95% CI, 0.40 to 0.94) predicated RT omission. Conclusion: Notable variation in care by geographic and surgical provider characteristics provides targets for further research in underserved areas.

AB - Purpose: We describe individual, area, and provider characteristics associated with care patterns for early-stage breast cancer in Appalachian counties of Kentucky, North Carolina, Ohio, and Pennsylvania. Methods: Cases of stages I to III breast cancer from 2006 to 2008 were linked to Medicare claims occurring within 1 year of diagnosis. Rates of guideline-concordant endocrine therapy (n = 1,429), chemotherapy (n = 1,480), and radiation therapy (RT) after breast-conserving surgery were studied; RT was studied in women age ≥ 70 years with stage I estrogen receptor (ER)-positive/progesterone receptor (PR)-positive cancer, for whom RT was optional (n = 1,108), and in all others, for whom RT was guideline concordant (n = 1,422). Univariable and multivariable analyses were performed. Independent variables included age, race, county-level economic status, state, surgeon graduation year and volume, comorbidity, diagnosis year, Medicaid/Medicare dual status, histology, tumor size, tumor sequence, positive lymph nodes, ER/PR status, stage, trastuzumab use, and surgery type. Results: Population mean age was 74 years; 97% were white. For endocrine therapy, chemotherapy, and RT, guideline concordance was 76%, 48%, and 83%, respectively. Where it was optional, 77% received RT. Guideline-concordant endocrine therapy was lower in North Carolina versus Pennsylvania (odds ratio [OR], 0.60; 95% CI, 0.41 to 0.88) and higher if surgeon graduated between 1984 and 1988 versus ≥ 1989 (OR, 1.58; 95% CI, 1.06 to 2.34). Guideline-concordant chemotherapy varied significantly by state, county-level economic status, and surgeon volume. In guideline-concordant RT, lower surgeon volume (v highest) predicted RT use (OR, 1.63; 95% CI, 1.61 to 2.36). In optional RT, North Carolina residence (v Pennsylvania; OR, 0.29; 95% CI, 0.17 to 0.48) and counties with higher economic status (OR, 0.61; 95% CI, 0.40 to 0.94) predicated RT omission. Conclusion: Notable variation in care by geographic and surgical provider characteristics provides targets for further research in underserved areas.

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