Individual pituitary neuropeptides do not recapitulate the effects of repository corticotropin (Acthar®) on human B cells in vitro

Ann L. Benko; A. Dale Wright; Teresa Sunyer; Nancy J. Olsen; William J. Kovacs

doi:10.1016/j.jneuroim.2021.577522

Individual pituitary neuropeptides do not recapitulate the effects of repository corticotropin (Acthar®) on human B cells in vitro

Ann L. Benko, A. Dale Wright, Teresa Sunyer, Nancy J. Olsen, William J. Kovacs

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2 Scopus citations

Abstract

Repository corticotropin injection (RCI), a complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides, has been found to suppress key aspects of gene expression and cellular function in human B lymphocytes in vitro. The present studies reveal that neither individual POMC peptides (α-MSH, ACTH_1-39, ACTH_1-24, β-endorphin) nor other related pituitary neuropeptides are sufficient to elicit these effects, even though specific receptors capable of transmitting signals from these peptides are expressed by human B cells. RCI's direct effects on human B cells may require complementary signals from multiple components of the preparation.

Original language	English (US)
Article number	577522
Journal	Journal of Neuroimmunology
Volume	353
DOIs	https://doi.org/10.1016/j.jneuroim.2021.577522
State	Published - Apr 15 2021

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2021.577522

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title = "Individual pituitary neuropeptides do not recapitulate the effects of repository corticotropin (Acthar{\textregistered}) on human B cells in vitro",

abstract = "Repository corticotropin injection (RCI), a complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides, has been found to suppress key aspects of gene expression and cellular function in human B lymphocytes in vitro. The present studies reveal that neither individual POMC peptides (α-MSH, ACTH1-39, ACTH1-24, β-endorphin) nor other related pituitary neuropeptides are sufficient to elicit these effects, even though specific receptors capable of transmitting signals from these peptides are expressed by human B cells. RCI's direct effects on human B cells may require complementary signals from multiple components of the preparation.",

author = "Benko, {Ann L.} and Wright, {A. Dale} and Teresa Sunyer and Olsen, {Nancy J.} and Kovacs, {William J.}",

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T1 - Individual pituitary neuropeptides do not recapitulate the effects of repository corticotropin (Acthar®) on human B cells in vitro

AU - Benko, Ann L.

AU - Wright, A. Dale

AU - Sunyer, Teresa

AU - Olsen, Nancy J.

AU - Kovacs, William J.

PY - 2021/4/15

Y1 - 2021/4/15

N2 - Repository corticotropin injection (RCI), a complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides, has been found to suppress key aspects of gene expression and cellular function in human B lymphocytes in vitro. The present studies reveal that neither individual POMC peptides (α-MSH, ACTH1-39, ACTH1-24, β-endorphin) nor other related pituitary neuropeptides are sufficient to elicit these effects, even though specific receptors capable of transmitting signals from these peptides are expressed by human B cells. RCI's direct effects on human B cells may require complementary signals from multiple components of the preparation.

AB - Repository corticotropin injection (RCI), a complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides, has been found to suppress key aspects of gene expression and cellular function in human B lymphocytes in vitro. The present studies reveal that neither individual POMC peptides (α-MSH, ACTH1-39, ACTH1-24, β-endorphin) nor other related pituitary neuropeptides are sufficient to elicit these effects, even though specific receptors capable of transmitting signals from these peptides are expressed by human B cells. RCI's direct effects on human B cells may require complementary signals from multiple components of the preparation.

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DO - 10.1016/j.jneuroim.2021.577522

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Individual pituitary neuropeptides do not recapitulate the effects of repository corticotropin (Acthar®) on human B cells in vitro

Abstract

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