Abstract

Background: Infrared fluorescence imaging with indocyanine green (ICG) is a novel method for sentinel node localization. Our objective was to assess ICG and fluorescence imaging for preoperative and intraoperative utility. Methods: 87 eligible patients participated in this prospective study. All patients received injection of ICG dye in addition to both methylene blue and 99mTc. Each sentinel node was assessed for the presence of each dye. Results: ICG was visible prior to incision in 44% of subjects. 99mTc identified a mean of 1.89 SLN per patient. ICG identified a mean of 1.87 SLN while methylene blue (MB) dye identified a mean of 0.71 SLN. 99mTc and ICG identified the same number of sentinel nodes per patient (P =.73) while methylene blue was inferior in its ability to localize sentinel nodes (P <.001). Conclusion: Our findings indicate that ICG/fluorescence imaging has limited ability to identify the nodal basin preoperatively, but is equivalent to 99mTc for intraoperative identification of sentinel nodes and superior to MB.

Original languageEnglish (US)
Pages (from-to)558-561
Number of pages4
JournalAmerican Journal of Surgery
Volume216
Issue number3
DOIs
StatePublished - Sep 1 2018

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Lymphography
Indocyanine Green
Melanoma
Fluorescence
Methylene Blue
Optical Imaging
Coloring Agents
cyhalothrin
Prospective Studies
Injections

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

@article{7c8acb8e2ba74fc2b34fce05e495e005,
title = "Indocyanine green and fluorescence lymphangiography for sentinel node identification in patients with melanoma",
abstract = "Background: Infrared fluorescence imaging with indocyanine green (ICG) is a novel method for sentinel node localization. Our objective was to assess ICG and fluorescence imaging for preoperative and intraoperative utility. Methods: 87 eligible patients participated in this prospective study. All patients received injection of ICG dye in addition to both methylene blue and 99mTc. Each sentinel node was assessed for the presence of each dye. Results: ICG was visible prior to incision in 44{\%} of subjects. 99mTc identified a mean of 1.89 SLN per patient. ICG identified a mean of 1.87 SLN while methylene blue (MB) dye identified a mean of 0.71 SLN. 99mTc and ICG identified the same number of sentinel nodes per patient (P =.73) while methylene blue was inferior in its ability to localize sentinel nodes (P <.001). Conclusion: Our findings indicate that ICG/fluorescence imaging has limited ability to identify the nodal basin preoperatively, but is equivalent to 99mTc for intraoperative identification of sentinel nodes and superior to MB.",
author = "Pameijer, {Colette R.} and Anna Leung and Rogerio Neves and Junjia Zhu",
year = "2018",
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doi = "10.1016/j.amjsurg.2018.01.009",
language = "English (US)",
volume = "216",
pages = "558--561",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Indocyanine green and fluorescence lymphangiography for sentinel node identification in patients with melanoma

AU - Pameijer, Colette R.

AU - Leung, Anna

AU - Neves, Rogerio

AU - Zhu, Junjia

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: Infrared fluorescence imaging with indocyanine green (ICG) is a novel method for sentinel node localization. Our objective was to assess ICG and fluorescence imaging for preoperative and intraoperative utility. Methods: 87 eligible patients participated in this prospective study. All patients received injection of ICG dye in addition to both methylene blue and 99mTc. Each sentinel node was assessed for the presence of each dye. Results: ICG was visible prior to incision in 44% of subjects. 99mTc identified a mean of 1.89 SLN per patient. ICG identified a mean of 1.87 SLN while methylene blue (MB) dye identified a mean of 0.71 SLN. 99mTc and ICG identified the same number of sentinel nodes per patient (P =.73) while methylene blue was inferior in its ability to localize sentinel nodes (P <.001). Conclusion: Our findings indicate that ICG/fluorescence imaging has limited ability to identify the nodal basin preoperatively, but is equivalent to 99mTc for intraoperative identification of sentinel nodes and superior to MB.

AB - Background: Infrared fluorescence imaging with indocyanine green (ICG) is a novel method for sentinel node localization. Our objective was to assess ICG and fluorescence imaging for preoperative and intraoperative utility. Methods: 87 eligible patients participated in this prospective study. All patients received injection of ICG dye in addition to both methylene blue and 99mTc. Each sentinel node was assessed for the presence of each dye. Results: ICG was visible prior to incision in 44% of subjects. 99mTc identified a mean of 1.89 SLN per patient. ICG identified a mean of 1.87 SLN while methylene blue (MB) dye identified a mean of 0.71 SLN. 99mTc and ICG identified the same number of sentinel nodes per patient (P =.73) while methylene blue was inferior in its ability to localize sentinel nodes (P <.001). Conclusion: Our findings indicate that ICG/fluorescence imaging has limited ability to identify the nodal basin preoperatively, but is equivalent to 99mTc for intraoperative identification of sentinel nodes and superior to MB.

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