Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts

Sujuan Yang, Ximei Zhang, Jingrong Chen, Junlong Dang, Rongzhen Liang, Donglan Zeng, Huan Zhang, Youqiu Xue, Yan Liu, Wenbin Wu, Jun Zhao, Julie Wang, Yunfeng Pan, Hanshi Xu, Bing Sun, Feng Huang, Yan Lu, Willa Hsueh, Nancy Olsen, Song Guo Zheng

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Aberrant number and/or dysfunction of CD4+Foxp3+ Regulatory T cells (Tregs) are associated with the pathogenesis of rheumatoid arthritis (RA). A previous study has demonstrated that thymus-derived, natural Tregs (nTregs) prefer to accumulate in inflamed joints and transdifferentiate to TH17 cells under the stimulation of inflamed synovial fibroblasts (SFs). In this study, we made a head-to-head comparison of both Treg subsets and demonstrated that induced Tregs (iTregs), but not nTregs, retained Foxp3 expression and regulatory function on T effector cells (Teffs) after being primed with inflamed SFs. In addition, iTregs inhibited proliferation, inflammatory cytokine production, migration, and invasion ability of collagen-induced arthritis (CIA)-SFs in vitro and in vivo. Moreover, we noted that iTregs directly targeted inflamed SFs to treat autoimmune arthritis, while nTregs failed to do this. Thus, manipulation of the iTreg subset may have a greater potential for prevention or treatment of patients with RA.

Original languageEnglish (US)
Article numberabb0606
JournalScience Advances
Volume6
Issue number44
DOIs
StatePublished - Oct 28 2020

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts'. Together they form a unique fingerprint.

Cite this