Induction of antigen-specific immune tolerance by TGF-β-induced CD4+Foxp3+ regulatory T cells

Huimin Fan, Julie Wang, Xiaohui Zhou, Zhongmin Liu, Song Guo Zheng

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Like natural CD4+CD25+ Treg cells, TGF-β-induced Treg cells also prevent allograft rejection in MHCmismatched organ transplantation models. In analyzing this effect with greater detail, we determined that injection of TGF-β-induced, alloactivated CD4 +CD25+ cells induces antigen-specific immune tolerance in vivo. Increased CD4+CD25+ cells in recipients contribute to this immune tolerance. In addition, adoptive transfer of TGF-β-induced CD4+CD25+ cells did not result in significant toxic and side effects in recipients. These results indicate that TGF-β-induced, alloactivated CD4+CD25+ cells may provide a safe and effective approach to protect MHC-mismatched organ grafts from rejection in a clinical setting.

Original languageEnglish (US)
Pages (from-to)212-220
Number of pages9
JournalInternational Journal of Clinical and Experimental Medicine
Volume2
Issue number3
StatePublished - Dec 1 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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