Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells

R. Poulin, G. Pelletier, Anthony Pegg

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Abstract

Deregulation of polyamine transport in L1210 cells overexpressing ornithine decarboxylase leads to a lethal accumulation of spermidine. We now provide evidence that overaccumulation of natural and synthetic polyamines, but not putrescine, rapidly induces apoptosis, as shown by hypercondensation of peripheral chromatin and internucleosomal cleavage, followed by nuclear fragmentation. Polyamine oxidation is not responsible for the apoptosis observed. Thus, abnormally high polyamine pools could be an important physiological trigger of apoptosis.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalBiochemical Journal
Volume311
Issue number3
DOIs
Publication statusPublished - Jan 1 1995

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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