Induction of ornithine decarboxylase in colon and liver by starvation and refeeding: A comparison of effects on total and holoenzyme

Bruce A. Stanley, Michael N. Kazarinoff

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

In rats, short-term starvation and subsequent refecding induced both holo- and total ornithine decarboxylase (EC 4.1.1.17) levels in colon 5-fold over ad lib fed controls. Starvation alone led to a significant decrease in total ornithine decarboxylase level in colon, while no change was seen in the holoenzyme level. There are only two reported short-term chemical inducers of colon ornithine decarboxylase, and this is the first demonstration of dietary induction in this tissue. Liver total ornithine decarboxylase was also induced by starvation-refeeding, but no holoenzyme effects were seen in any treatment.

Original languageEnglish (US)
Pages (from-to)773-777
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume105
Issue number2
DOIs
StatePublished - Mar 30 1982

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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