Induction of polyomavirus-specific CD8+ T lymphocytes by distinct dendritic cell subpopulations

D. R. Drake, M. L. Shawver, A. Hadley, E. Butz, C. Maliszewski, A. E. Lukacher

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Dendritic cells are pivotal antigen-presenting cells for generating adaptive T-cell responses. Here, we show that dendritic cells belonging to either the myeloid-related or lymphoid-related subset are permissive for infection by mouse polyomavirus and, when loaded with a peptide corresponding to the immunodominant anti-polyomavirus CD8+ T-cell epitope or infected by polyomavirus, are each capable of driving expansion of primary polyomavirus-specific CD8+ T-cell responses in vivo.

Original languageEnglish (US)
Pages (from-to)544-547
Number of pages4
JournalJournal of virology
Volume75
Issue number1
DOIs
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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