Induction of senescence by adenosine suppressing the growth of lung cancer cells

Dongqin Yang, Junyao Song, Lijun Wu, Yunfang Ma, Chunhua Song, Sinisa Dovat, Tomoyuki Nishizaki, Jie Liu

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Extracellular adenosine is well reported to suppress tumor growth by induction of apoptosis. However, in this study we found that adenosine treatment results in cellular senescence in A549 lung cancer cells both in vitro and in vivo; adenosine induces cell cycle arrest and senescence in a p53/p21 dependent manner; adenosine elevates the level of phosphor-γH2AX, pCHK2 and pBRCA1, the markers for prolonged DNA damage response which are likely responsible for initiating the cellular senescence. Our study first demonstrates that adenosine suppresses growth of cancer cells by inducing senescence and provides additional evidence that adenosine could act as an effective anticancer agent for targeted cancer therapy.

Original languageEnglish (US)
Pages (from-to)62-67
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume440
Issue number1
DOIs
StatePublished - Oct 11 2013

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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