TY - JOUR
T1 - Induction of T cell responses in nonresponder mice by abolishing suppression with monoclonal antibodies recognizing a region-controlled, T cell-specific determinants
AU - Ikezawa, Z.
AU - Nonaka, M.
AU - Abe, R.
AU - Tada, T.
AU - Nagy, Z. A.
AU - Klein, J.
PY - 1983/12/4
Y1 - 1983/12/4
N2 - Mouse strains carrying the k allele at loci A(β), A(α), E(β), and E(α) are nonresponders to lactate dehydrogenase B (LDH(B)) and to allotypic determinants of IgG2a myeloma proteins (for example, UPC10 used in this study). The nonresponsiveness to these antigens is caused by T suppressor (Ts) cells that prevent antigen-primed T helper (Th) cells from proliferating. We demonstrate here that monoclonal antibodies specific for an A region-controlled molecule selectively expressed on T cells (A-T) are capable of inducing anti-LDH(B) and anti-UPC10 responses of primed T cells from nonresponder strains. A monoclonal anti-J antibody that cross-reacts with the A-T molecule also induces responsiveness, whereas another J-specific antibody that lacks this cross-reactivity fails to do so. The mechanism of response induction is blocking of the interaction between the Ts cell or its factor (TsF) and the target of suppression, the antigen-specific Lyt-1+2- (Th) cell. The blocking occurs at the level of the Ts cell and the TsF. The data indicate that Ts cells and TsF carry a unique, A region-controlled molecule that is not only functionally analogous but also serologically similar to the J molecule.
AB - Mouse strains carrying the k allele at loci A(β), A(α), E(β), and E(α) are nonresponders to lactate dehydrogenase B (LDH(B)) and to allotypic determinants of IgG2a myeloma proteins (for example, UPC10 used in this study). The nonresponsiveness to these antigens is caused by T suppressor (Ts) cells that prevent antigen-primed T helper (Th) cells from proliferating. We demonstrate here that monoclonal antibodies specific for an A region-controlled molecule selectively expressed on T cells (A-T) are capable of inducing anti-LDH(B) and anti-UPC10 responses of primed T cells from nonresponder strains. A monoclonal anti-J antibody that cross-reacts with the A-T molecule also induces responsiveness, whereas another J-specific antibody that lacks this cross-reactivity fails to do so. The mechanism of response induction is blocking of the interaction between the Ts cell or its factor (TsF) and the target of suppression, the antigen-specific Lyt-1+2- (Th) cell. The blocking occurs at the level of the Ts cell and the TsF. The data indicate that Ts cells and TsF carry a unique, A region-controlled molecule that is not only functionally analogous but also serologically similar to the J molecule.
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M3 - Article
C2 - 6194210
AN - SCOPUS:0020544875
VL - 131
SP - 1646
EP - 1649
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 4
ER -