Abstract
Plasmodium vivax is now the predominant species causing malarial infection and disease in most non-African areas, but little is known about its transmission efficiency from human to mosquitoes. Because the majority of Plasmodium infections in endemic areas are low density and asymptomatic, it is important to evaluate how well these infections transmit. Using membrane feeding apparatus, Anopheles dirus were fed with blood samples from 94 individuals who had natural P. vivax infections with parasitemias spanning four orders of magnitude. We found that the mosquito infection rate was positively correlated with blood parasitemia and that infection began to rise when parasitemia was >10 parasites/μl. Below this threshold, mosquito infection is rare and associated with very few oocysts. These findings provide useful information for assessing the human reservoir of transmission and for establishing diagnostic sensitivity required to identify individuals who are most infective to mosquitoes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 163-170 |
| Number of pages | 8 |
| Journal | International Journal for Parasitology |
| Volume | 47 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Feb 1 2017 |
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All Science Journal Classification (ASJC) codes
- Parasitology
- Infectious Diseases
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Infectivity of symptomatic and asymptomatic Plasmodium vivax infections to a Southeast Asian vector, Anopheles dirus. / Kiattibutr, Kirakorn; Roobsoong, Wanlapa; Sriwichai, Patchara; Saeseu, Teerawat; Rachaphaew, Nattawan; Suansomjit, Chayanut; Buates, Sureemas; Obadia, Thomas; Mueller, Ivo; Cui, Liwang; Nguitragool, Wang; Sattabongkot, Jetsumon.
In: International Journal for Parasitology, Vol. 47, No. 2-3, 01.02.2017, p. 163-170.Research output: Contribution to journal › Article
TY - JOUR
T1 - Infectivity of symptomatic and asymptomatic Plasmodium vivax infections to a Southeast Asian vector, Anopheles dirus
AU - Kiattibutr, Kirakorn
AU - Roobsoong, Wanlapa
AU - Sriwichai, Patchara
AU - Saeseu, Teerawat
AU - Rachaphaew, Nattawan
AU - Suansomjit, Chayanut
AU - Buates, Sureemas
AU - Obadia, Thomas
AU - Mueller, Ivo
AU - Cui, Liwang
AU - Nguitragool, Wang
AU - Sattabongkot, Jetsumon
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Plasmodium vivax is now the predominant species causing malarial infection and disease in most non-African areas, but little is known about its transmission efficiency from human to mosquitoes. Because the majority of Plasmodium infections in endemic areas are low density and asymptomatic, it is important to evaluate how well these infections transmit. Using membrane feeding apparatus, Anopheles dirus were fed with blood samples from 94 individuals who had natural P. vivax infections with parasitemias spanning four orders of magnitude. We found that the mosquito infection rate was positively correlated with blood parasitemia and that infection began to rise when parasitemia was >10 parasites/μl. Below this threshold, mosquito infection is rare and associated with very few oocysts. These findings provide useful information for assessing the human reservoir of transmission and for establishing diagnostic sensitivity required to identify individuals who are most infective to mosquitoes.
AB - Plasmodium vivax is now the predominant species causing malarial infection and disease in most non-African areas, but little is known about its transmission efficiency from human to mosquitoes. Because the majority of Plasmodium infections in endemic areas are low density and asymptomatic, it is important to evaluate how well these infections transmit. Using membrane feeding apparatus, Anopheles dirus were fed with blood samples from 94 individuals who had natural P. vivax infections with parasitemias spanning four orders of magnitude. We found that the mosquito infection rate was positively correlated with blood parasitemia and that infection began to rise when parasitemia was >10 parasites/μl. Below this threshold, mosquito infection is rare and associated with very few oocysts. These findings provide useful information for assessing the human reservoir of transmission and for establishing diagnostic sensitivity required to identify individuals who are most infective to mosquitoes.
UR - http://www.scopus.com/inward/record.url?scp=85009727698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85009727698&partnerID=8YFLogxK
U2 - 10.1016/j.ijpara.2016.10.006
DO - 10.1016/j.ijpara.2016.10.006
M3 - Article
C2 - 28043858
AN - SCOPUS:85009727698
VL - 47
SP - 163
EP - 170
JO - International Journal for Parasitology
JF - International Journal for Parasitology
SN - 0020-7519
IS - 2-3
ER -