Inflammasome activation by propionibacterium acnes: The story of il-1 in acne continues to unfold

Research output: Contribution to journalComment/debate

14 Citations (Scopus)

Abstract

Insights into the immune mechanisms at play in skin diseases including acne continue to be made. In this issue, Kistowska et al. confirm that Propionibacterium acnes activates inflammasomes leading to the production of IL-1β and they further identify putative mechanisms by which this process occurs. These data raise interesting questions regarding a multipronged approach by which P. acnes elicits inflammation in early versus late acne and putative differences in the effects of IL-1α and IL-1β in this disease process.

Original languageEnglish (US)
Pages (from-to)595-597
Number of pages3
JournalJournal of Investigative Dermatology
Volume134
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Inflammasomes
Propionibacterium acnes
Acne Vulgaris
Interleukin-1
Chemical activation
Skin Diseases
Skin
Inflammation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

@article{b4f830afa35d4742b1847c7d7de5ef16,
title = "Inflammasome activation by propionibacterium acnes: The story of il-1 in acne continues to unfold",
abstract = "Insights into the immune mechanisms at play in skin diseases including acne continue to be made. In this issue, Kistowska et al. confirm that Propionibacterium acnes activates inflammasomes leading to the production of IL-1β and they further identify putative mechanisms by which this process occurs. These data raise interesting questions regarding a multipronged approach by which P. acnes elicits inflammation in early versus late acne and putative differences in the effects of IL-1α and IL-1β in this disease process.",
author = "Thiboutot, {Diane M.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1038/jid.2013.528",
language = "English (US)",
volume = "134",
pages = "595--597",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
number = "3",

}

Inflammasome activation by propionibacterium acnes : The story of il-1 in acne continues to unfold. / Thiboutot, Diane M.

In: Journal of Investigative Dermatology, Vol. 134, No. 3, 01.01.2014, p. 595-597.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Inflammasome activation by propionibacterium acnes

T2 - The story of il-1 in acne continues to unfold

AU - Thiboutot, Diane M.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Insights into the immune mechanisms at play in skin diseases including acne continue to be made. In this issue, Kistowska et al. confirm that Propionibacterium acnes activates inflammasomes leading to the production of IL-1β and they further identify putative mechanisms by which this process occurs. These data raise interesting questions regarding a multipronged approach by which P. acnes elicits inflammation in early versus late acne and putative differences in the effects of IL-1α and IL-1β in this disease process.

AB - Insights into the immune mechanisms at play in skin diseases including acne continue to be made. In this issue, Kistowska et al. confirm that Propionibacterium acnes activates inflammasomes leading to the production of IL-1β and they further identify putative mechanisms by which this process occurs. These data raise interesting questions regarding a multipronged approach by which P. acnes elicits inflammation in early versus late acne and putative differences in the effects of IL-1α and IL-1β in this disease process.

UR - http://www.scopus.com/inward/record.url?scp=84894098594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894098594&partnerID=8YFLogxK

U2 - 10.1038/jid.2013.528

DO - 10.1038/jid.2013.528

M3 - Comment/debate

C2 - 24518111

AN - SCOPUS:84894098594

VL - 134

SP - 595

EP - 597

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 3

ER -