Inflammation and acute traffic-related air pollution exposures among a cohort of youth with type 1 diabetes

Robin C. Puett, Jeff D. Yanosky, Murray A. Mittleman, Jessica Montresor-Lopez, Ronny A. Bell, Tessa L. Crume, Dana Dabelea, Lawrence M. Dolan, Ralph B. D'Agostino, Santica M. Marcovina, Catherine Pihoker, Kristi Reynolds, Elaine Urbina, Angela D. Liese

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Abstract

Background: Evidence remains equivocal regarding the association of inflammation, a precursor to cardiovascular disease, and acute exposures to ambient air pollution from traffic-related particulate matter. Though youth with type 1 diabetes are at higher risk for cardiovascular disease, the relationship of inflammation and ambient air pollution exposures in this population has received little attention. Objectives: Using five geographically diverse US sites from the racially- and ethnically-diverse SEARCH for Diabetes in Youth Cohort, we examined the relationship of acute exposures to PM2.5 mass, Atmospheric Dispersion Modeling System (ADMS)-Roads traffic-related PM concentrations near roadways, and elemental carbon (EC) with biomarkers of inflammation including interleukin-6 (IL-6), c-reactive protein (hs-CRP) and fibrinogen. Methods: Baseline questionnaires and blood were obtained at a study visit. Using a spatio-temporal modeling approach, pollutant exposures for 7 days prior to blood draw were assigned to residential addresses. Linear mixed models for each outcome and exposure were adjusted for demographic and lifestyle factors identified a priori. Results: Among the 2566 participants with complete data, fully-adjusted models showed positive associations of EC average week exposures with IL-6 and hs-CRP, and PM2.5 mass exposures on lag day 3 with IL-6 levels. Comparing the 25th and 75th percentiles of average week EC exposures resulted in 8.3% higher IL-6 (95%CI: 2.7%,14.3%) and 9.8% higher hs-CRP (95%CI: 2.4%,17.7%). We observed some evidence of effect modification for the relationships of PM2.5 mass exposures with hs-CRP by gender and with IL-6 by race/ethnicity. Conclusions: Indicators of inflammation were associated with estimated traffic-related air pollutant exposures in this study population of youth with type 1 diabetes. Thus youth with type 1 diabetes may be at increased risk of air pollution-related inflammation. These findings and the racial/ethnic and gender differences observed deserve further exploration.

Original languageEnglish (US)
Article number105064
JournalEnvironment International
Volume132
DOIs
StatePublished - Nov 2019

All Science Journal Classification (ASJC) codes

  • Environmental Science(all)

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    Puett, R. C., Yanosky, J. D., Mittleman, M. A., Montresor-Lopez, J., Bell, R. A., Crume, T. L., Dabelea, D., Dolan, L. M., D'Agostino, R. B., Marcovina, S. M., Pihoker, C., Reynolds, K., Urbina, E., & Liese, A. D. (2019). Inflammation and acute traffic-related air pollution exposures among a cohort of youth with type 1 diabetes. Environment International, 132, [105064]. https://doi.org/10.1016/j.envint.2019.105064