Inflammatory bowel disease- And Barrett's esophagus-associated neoplasia- And old, the new, and the persistent struggles

Dipti M. Karamchandani, Qin Zhang, Xiao Yan Liao, Jing Hong Xu, Xiu Li Liu

Research output: Contribution to journalReview articlepeer-review

Abstract

Early diagnosis of and adequate therapy for premalignant lesions in patients with inflammatory bowel disease (IBD) and Barrett's esophagus (BE) has been shown to decrease mortality. Endoscopic examination with histologic evaluation of random and targeted biopsies remains the gold standard for early detection and adequate treatment of neoplasia in both these diseases. Although eventual patient management (including surveillance and treatment) depends upon a precise histologic assessment of the initial biopsy, accurately diagnosing and grading IBD- and BE-associated dysplasia is still considered challenging by many general as well as subspecialized pathologists. Additionally, there are continuing updates in the literature regarding the diagnosis, surveillance, and treatment of these disease entities. This comprehensive review discusses the cancer risk, detailed histopathological features, diagnostic challenges, and updates as well as the latest surveillance and treatment recommendations in IBD- and BE-associated dysplasia.

Original languageEnglish (US)
Pages (from-to)379-395
Number of pages17
JournalGastroenterology Report
Volume7
Issue number6
DOIs
StatePublished - Dec 1 2019

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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