Inflammatory cytokine and humoral responses to plasmodium falciparum glycosylphosphatidylinositols correlates with malaria immunity and pathogenesis

Babacar Mbengue, Birahim Niang, Maguette Sylla Niang, Marie Louise Varela, Becaye Fall, Mouhamadou Mansour Fall, Rokhaya Ndiaye Diallo, Bacary Diatta, D. Channe Gowda, Alioune Dieye, Ronald Perraut

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Pro-inflammatory cytokines induced by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum contribute to malaria pathogenesis and hence, the naturally acquired anti-GPI antibody thought to provide protection against severe malaria (SM) by neutralizing the stimulatory activity of GPIs. In previous studies, the anti-GPI antibody levels increased with age in parallel with the development of acquired immunity, and high levels of anti-GPI antibodies were associated with mild malaria (MM) cases. In the present study, the relationship between the levels of pro-inflammatory cytokines and anti-GPI IgG antibody responses, parasitemia, and the clinical outcomes were evaluated in SM and mild malaria (MM) patients. Sera from a total of 110 SM and 72 MM cases after excluding of ineligible patients were analyzed for the levels of anti-GPI antibodies, IgG subclasses, and cytokine responses by ELISA. While the total anti-GPI antibody levels were similar in overall SM and MM groups, they were significantly higher in surviving SM patients than in fatal SM cases. In the case of cytokines, the TNF-α and IL-6 levels were significantly higher in SM compared to MM, whereas the IL-10 levels were similar in both groups. The data presented here demonstrate that high levels of the circulatory proinflammatory, TNF-α, and IL-6, are indicators of malaria severity, whereas antiinflammatory cytokine IL-10 level does not differentiate SM and MM cases. Further, among SM patients, relatively low levels of anti-GPI antibodies are indicators of fatal outcomes compared to survivors, suggesting that anti-GPI antibodies provide some level of protection against SM fatality.

Original languageEnglish (US)
Pages (from-to)24-34
Number of pages11
JournalImmunity Inflammation and Disease
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2016

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Glycosylphosphatidylinositols
Plasmodium falciparum
Malaria
Immunity
Cytokines
Anti-Idiotypic Antibodies
Interleukin-10
Interleukin-6
Fatal Outcome
Parasitemia

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Mbengue, Babacar ; Niang, Birahim ; Sylla Niang, Maguette ; Varela, Marie Louise ; Fall, Becaye ; Fall, Mouhamadou Mansour ; Ndiaye Diallo, Rokhaya ; Diatta, Bacary ; Gowda, D. Channe ; Dieye, Alioune ; Perraut, Ronald. / Inflammatory cytokine and humoral responses to plasmodium falciparum glycosylphosphatidylinositols correlates with malaria immunity and pathogenesis. In: Immunity Inflammation and Disease. 2016 ; Vol. 4, No. 1. pp. 24-34.
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title = "Inflammatory cytokine and humoral responses to plasmodium falciparum glycosylphosphatidylinositols correlates with malaria immunity and pathogenesis",
abstract = "Pro-inflammatory cytokines induced by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum contribute to malaria pathogenesis and hence, the naturally acquired anti-GPI antibody thought to provide protection against severe malaria (SM) by neutralizing the stimulatory activity of GPIs. In previous studies, the anti-GPI antibody levels increased with age in parallel with the development of acquired immunity, and high levels of anti-GPI antibodies were associated with mild malaria (MM) cases. In the present study, the relationship between the levels of pro-inflammatory cytokines and anti-GPI IgG antibody responses, parasitemia, and the clinical outcomes were evaluated in SM and mild malaria (MM) patients. Sera from a total of 110 SM and 72 MM cases after excluding of ineligible patients were analyzed for the levels of anti-GPI antibodies, IgG subclasses, and cytokine responses by ELISA. While the total anti-GPI antibody levels were similar in overall SM and MM groups, they were significantly higher in surviving SM patients than in fatal SM cases. In the case of cytokines, the TNF-α and IL-6 levels were significantly higher in SM compared to MM, whereas the IL-10 levels were similar in both groups. The data presented here demonstrate that high levels of the circulatory proinflammatory, TNF-α, and IL-6, are indicators of malaria severity, whereas antiinflammatory cytokine IL-10 level does not differentiate SM and MM cases. Further, among SM patients, relatively low levels of anti-GPI antibodies are indicators of fatal outcomes compared to survivors, suggesting that anti-GPI antibodies provide some level of protection against SM fatality.",
author = "Babacar Mbengue and Birahim Niang and {Sylla Niang}, Maguette and Varela, {Marie Louise} and Becaye Fall and Fall, {Mouhamadou Mansour} and {Ndiaye Diallo}, Rokhaya and Bacary Diatta and Gowda, {D. Channe} and Alioune Dieye and Ronald Perraut",
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Mbengue, B, Niang, B, Sylla Niang, M, Varela, ML, Fall, B, Fall, MM, Ndiaye Diallo, R, Diatta, B, Gowda, DC, Dieye, A & Perraut, R 2016, 'Inflammatory cytokine and humoral responses to plasmodium falciparum glycosylphosphatidylinositols correlates with malaria immunity and pathogenesis', Immunity Inflammation and Disease, vol. 4, no. 1, pp. 24-34. https://doi.org/10.1002/iid3.89

Inflammatory cytokine and humoral responses to plasmodium falciparum glycosylphosphatidylinositols correlates with malaria immunity and pathogenesis. / Mbengue, Babacar; Niang, Birahim; Sylla Niang, Maguette; Varela, Marie Louise; Fall, Becaye; Fall, Mouhamadou Mansour; Ndiaye Diallo, Rokhaya; Diatta, Bacary; Gowda, D. Channe; Dieye, Alioune; Perraut, Ronald.

In: Immunity Inflammation and Disease, Vol. 4, No. 1, 01.01.2016, p. 24-34.

Research output: Contribution to journalArticle

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T1 - Inflammatory cytokine and humoral responses to plasmodium falciparum glycosylphosphatidylinositols correlates with malaria immunity and pathogenesis

AU - Mbengue, Babacar

AU - Niang, Birahim

AU - Sylla Niang, Maguette

AU - Varela, Marie Louise

AU - Fall, Becaye

AU - Fall, Mouhamadou Mansour

AU - Ndiaye Diallo, Rokhaya

AU - Diatta, Bacary

AU - Gowda, D. Channe

AU - Dieye, Alioune

AU - Perraut, Ronald

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Pro-inflammatory cytokines induced by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum contribute to malaria pathogenesis and hence, the naturally acquired anti-GPI antibody thought to provide protection against severe malaria (SM) by neutralizing the stimulatory activity of GPIs. In previous studies, the anti-GPI antibody levels increased with age in parallel with the development of acquired immunity, and high levels of anti-GPI antibodies were associated with mild malaria (MM) cases. In the present study, the relationship between the levels of pro-inflammatory cytokines and anti-GPI IgG antibody responses, parasitemia, and the clinical outcomes were evaluated in SM and mild malaria (MM) patients. Sera from a total of 110 SM and 72 MM cases after excluding of ineligible patients were analyzed for the levels of anti-GPI antibodies, IgG subclasses, and cytokine responses by ELISA. While the total anti-GPI antibody levels were similar in overall SM and MM groups, they were significantly higher in surviving SM patients than in fatal SM cases. In the case of cytokines, the TNF-α and IL-6 levels were significantly higher in SM compared to MM, whereas the IL-10 levels were similar in both groups. The data presented here demonstrate that high levels of the circulatory proinflammatory, TNF-α, and IL-6, are indicators of malaria severity, whereas antiinflammatory cytokine IL-10 level does not differentiate SM and MM cases. Further, among SM patients, relatively low levels of anti-GPI antibodies are indicators of fatal outcomes compared to survivors, suggesting that anti-GPI antibodies provide some level of protection against SM fatality.

AB - Pro-inflammatory cytokines induced by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum contribute to malaria pathogenesis and hence, the naturally acquired anti-GPI antibody thought to provide protection against severe malaria (SM) by neutralizing the stimulatory activity of GPIs. In previous studies, the anti-GPI antibody levels increased with age in parallel with the development of acquired immunity, and high levels of anti-GPI antibodies were associated with mild malaria (MM) cases. In the present study, the relationship between the levels of pro-inflammatory cytokines and anti-GPI IgG antibody responses, parasitemia, and the clinical outcomes were evaluated in SM and mild malaria (MM) patients. Sera from a total of 110 SM and 72 MM cases after excluding of ineligible patients were analyzed for the levels of anti-GPI antibodies, IgG subclasses, and cytokine responses by ELISA. While the total anti-GPI antibody levels were similar in overall SM and MM groups, they were significantly higher in surviving SM patients than in fatal SM cases. In the case of cytokines, the TNF-α and IL-6 levels were significantly higher in SM compared to MM, whereas the IL-10 levels were similar in both groups. The data presented here demonstrate that high levels of the circulatory proinflammatory, TNF-α, and IL-6, are indicators of malaria severity, whereas antiinflammatory cytokine IL-10 level does not differentiate SM and MM cases. Further, among SM patients, relatively low levels of anti-GPI antibodies are indicators of fatal outcomes compared to survivors, suggesting that anti-GPI antibodies provide some level of protection against SM fatality.

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