Influence of diabetes on ambulation and inflammation in men and women with symptomatic peripheral artery disease

Andrew Gardner, Donald E. Parker, Polly S. Montgomery, Danuta Sosnowska, Ana I. Casanegra, Zoltan Ungvari, Anna Csiszar, Sarah X. Zhang, Josh J. Wang, William E. Sonntag

Research output: Contribution to journalArticle

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Abstract

Objective To determine whether diabetes and sex were factors associated with ambulatory function, endothelial cell inflammation, oxidative stress, and apoptosis, and with circulating biomarkers of inflammation and antioxidant capacity in patients with peripheral artery disease (PAD) and claudication. Materials/Methods Ambulatory function of 180 symptomatic men and women with PAD was assessed during a graded maximal treadmill test, 6-minute walk test, and 4-meter walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells, and on circulating inflammatory and vascular biomarkers. Results Men and women with diabetes had greater prevalence (p = 0.007 and p = 0.015, respectively) of coronary artery disease (CAD) than patients without diabetes. To assure that this difference did not influence planned comparisons, the data set was stratified on CAD. Diabetic men with CAD had a lower peak walking time (PWT) during the treadmill test and a slower 4-meter gait speed compared to non-diabetic men with CAD (p < 0.05). Diabetic women with CAD had a lower PWT compared to their non-diabetic counterparts (p < 0.01). Additionally, diabetic men with CAD had higher pigment epithelium-derived factor (p < 0.05) than their non-diabetic counterparts, and diabetic women with CAD had higher leptin (p < 0.01) and interleukin-8 levels (p < 0.05). Conclusions In patients with PAD, diabetic men and women with CAD had more severe claudication than their non-diabetic counterparts, as measured by shorter PWT, and the men had further ambulatory impairment manifested by slower 4-meter gait speed. Furthermore, the diabetic patients with CAD had elevations in interleukin-8, leptin, and PEDF.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalJournal of Clinical and Translational Endocrinology
Volume2
Issue number4
DOIs
StatePublished - Jan 1 2015

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Peripheral Arterial Disease
Walking
Coronary Artery Disease
Inflammation
Leptin
Interleukin-8
Exercise Test
Endothelial Cells
Biomarkers
Sex Factors
Biological Assay
Blood Vessels
Oxidative Stress
Cell Culture Techniques
Antioxidants
Apoptosis

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Gardner, Andrew ; Parker, Donald E. ; Montgomery, Polly S. ; Sosnowska, Danuta ; Casanegra, Ana I. ; Ungvari, Zoltan ; Csiszar, Anna ; Zhang, Sarah X. ; Wang, Josh J. ; Sonntag, William E. / Influence of diabetes on ambulation and inflammation in men and women with symptomatic peripheral artery disease. In: Journal of Clinical and Translational Endocrinology. 2015 ; Vol. 2, No. 4. pp. 137-143.
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abstract = "Objective To determine whether diabetes and sex were factors associated with ambulatory function, endothelial cell inflammation, oxidative stress, and apoptosis, and with circulating biomarkers of inflammation and antioxidant capacity in patients with peripheral artery disease (PAD) and claudication. Materials/Methods Ambulatory function of 180 symptomatic men and women with PAD was assessed during a graded maximal treadmill test, 6-minute walk test, and 4-meter walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells, and on circulating inflammatory and vascular biomarkers. Results Men and women with diabetes had greater prevalence (p = 0.007 and p = 0.015, respectively) of coronary artery disease (CAD) than patients without diabetes. To assure that this difference did not influence planned comparisons, the data set was stratified on CAD. Diabetic men with CAD had a lower peak walking time (PWT) during the treadmill test and a slower 4-meter gait speed compared to non-diabetic men with CAD (p < 0.05). Diabetic women with CAD had a lower PWT compared to their non-diabetic counterparts (p < 0.01). Additionally, diabetic men with CAD had higher pigment epithelium-derived factor (p < 0.05) than their non-diabetic counterparts, and diabetic women with CAD had higher leptin (p < 0.01) and interleukin-8 levels (p < 0.05). Conclusions In patients with PAD, diabetic men and women with CAD had more severe claudication than their non-diabetic counterparts, as measured by shorter PWT, and the men had further ambulatory impairment manifested by slower 4-meter gait speed. Furthermore, the diabetic patients with CAD had elevations in interleukin-8, leptin, and PEDF.",
author = "Andrew Gardner and Parker, {Donald E.} and Montgomery, {Polly S.} and Danuta Sosnowska and Casanegra, {Ana I.} and Zoltan Ungvari and Anna Csiszar and Zhang, {Sarah X.} and Wang, {Josh J.} and Sonntag, {William E.}",
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Gardner, A, Parker, DE, Montgomery, PS, Sosnowska, D, Casanegra, AI, Ungvari, Z, Csiszar, A, Zhang, SX, Wang, JJ & Sonntag, WE 2015, 'Influence of diabetes on ambulation and inflammation in men and women with symptomatic peripheral artery disease', Journal of Clinical and Translational Endocrinology, vol. 2, no. 4, pp. 137-143. https://doi.org/10.1016/j.jcte.2015.08.003

Influence of diabetes on ambulation and inflammation in men and women with symptomatic peripheral artery disease. / Gardner, Andrew; Parker, Donald E.; Montgomery, Polly S.; Sosnowska, Danuta; Casanegra, Ana I.; Ungvari, Zoltan; Csiszar, Anna; Zhang, Sarah X.; Wang, Josh J.; Sonntag, William E.

In: Journal of Clinical and Translational Endocrinology, Vol. 2, No. 4, 01.01.2015, p. 137-143.

Research output: Contribution to journalArticle

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T1 - Influence of diabetes on ambulation and inflammation in men and women with symptomatic peripheral artery disease

AU - Gardner, Andrew

AU - Parker, Donald E.

AU - Montgomery, Polly S.

AU - Sosnowska, Danuta

AU - Casanegra, Ana I.

AU - Ungvari, Zoltan

AU - Csiszar, Anna

AU - Zhang, Sarah X.

AU - Wang, Josh J.

AU - Sonntag, William E.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective To determine whether diabetes and sex were factors associated with ambulatory function, endothelial cell inflammation, oxidative stress, and apoptosis, and with circulating biomarkers of inflammation and antioxidant capacity in patients with peripheral artery disease (PAD) and claudication. Materials/Methods Ambulatory function of 180 symptomatic men and women with PAD was assessed during a graded maximal treadmill test, 6-minute walk test, and 4-meter walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells, and on circulating inflammatory and vascular biomarkers. Results Men and women with diabetes had greater prevalence (p = 0.007 and p = 0.015, respectively) of coronary artery disease (CAD) than patients without diabetes. To assure that this difference did not influence planned comparisons, the data set was stratified on CAD. Diabetic men with CAD had a lower peak walking time (PWT) during the treadmill test and a slower 4-meter gait speed compared to non-diabetic men with CAD (p < 0.05). Diabetic women with CAD had a lower PWT compared to their non-diabetic counterparts (p < 0.01). Additionally, diabetic men with CAD had higher pigment epithelium-derived factor (p < 0.05) than their non-diabetic counterparts, and diabetic women with CAD had higher leptin (p < 0.01) and interleukin-8 levels (p < 0.05). Conclusions In patients with PAD, diabetic men and women with CAD had more severe claudication than their non-diabetic counterparts, as measured by shorter PWT, and the men had further ambulatory impairment manifested by slower 4-meter gait speed. Furthermore, the diabetic patients with CAD had elevations in interleukin-8, leptin, and PEDF.

AB - Objective To determine whether diabetes and sex were factors associated with ambulatory function, endothelial cell inflammation, oxidative stress, and apoptosis, and with circulating biomarkers of inflammation and antioxidant capacity in patients with peripheral artery disease (PAD) and claudication. Materials/Methods Ambulatory function of 180 symptomatic men and women with PAD was assessed during a graded maximal treadmill test, 6-minute walk test, and 4-meter walk test. Patients were further characterized on endothelial effects of circulating factors present in the sera using a cell culture-based bioassay on primary human arterial endothelial cells, and on circulating inflammatory and vascular biomarkers. Results Men and women with diabetes had greater prevalence (p = 0.007 and p = 0.015, respectively) of coronary artery disease (CAD) than patients without diabetes. To assure that this difference did not influence planned comparisons, the data set was stratified on CAD. Diabetic men with CAD had a lower peak walking time (PWT) during the treadmill test and a slower 4-meter gait speed compared to non-diabetic men with CAD (p < 0.05). Diabetic women with CAD had a lower PWT compared to their non-diabetic counterparts (p < 0.01). Additionally, diabetic men with CAD had higher pigment epithelium-derived factor (p < 0.05) than their non-diabetic counterparts, and diabetic women with CAD had higher leptin (p < 0.01) and interleukin-8 levels (p < 0.05). Conclusions In patients with PAD, diabetic men and women with CAD had more severe claudication than their non-diabetic counterparts, as measured by shorter PWT, and the men had further ambulatory impairment manifested by slower 4-meter gait speed. Furthermore, the diabetic patients with CAD had elevations in interleukin-8, leptin, and PEDF.

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